Abstract
Beam F3 and 5.5 cm targeting show similar efficacy in rTMS treatment of depression: a randomized trial
Brain stimulation, Vol.16(4), p.3
07/2023
DOI: 10.1016/j.brs.2023.07.011
Abstract
Background: The two most common targeting methods for localizing the left dorsolateral prefrontal cortex (DLPFC) treatment site in repetitive transcranial magnetic stimulation (rTMS) include the Beam F3 and 5.5 cm method. They localize to different regions. We conducted a clinical trial to compare efficacy between them, with a prospective, randomized, single-blind design in a naturalistic sample of patients with major depressive disorder (MDD) undergoing clinical treatment.
Methods: 105 adult patients with MDD (mean age=43.2; range=18-73; 69 female) were randomized to receive rTMS to the Beam F3 or 5.5 cm target. Between group differences from pre- to post-treatment were evaluated with the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and clinician-administered Montgomery-Åsberg Depression Scale (MADRS). Primary treatment endpoint was completion of daily treatment series with at least 20 treatments. Subjects with head circumference >60 cm were excluded.
Results: No statistically significant differences were discovered on any measure between the F3 and 5.5 cm groups, including percent change (PHQ-9: 39% vs. 39%, n=94, p=0.95; GAD-7: 34% vs. 27%, n=76, p=0.50; MADRS: 40% vs. 38%, n=67, p=0.83), response rates (PHQ-9: 37% vs. 43%; GAD-7: 27% vs. 30%; MADRS: 43% vs. 43%), and remission rates (PHQ-9: 22% vs. 21%; MADRS: 20% vs. 19%). The study was terminated following interim analysis due to futility.
Conclusions: Similar antidepressant effects were observed with DLFPC rTMS using either the Beam F3 or 5.5 cm targeting method and may be equivalent for clinical use in patients with head circumference <60 cm. Comparison to MRI-based targeting requires further investigation.
Details
- Title: Subtitle
- Beam F3 and 5.5 cm targeting show similar efficacy in rTMS treatment of depression: a randomized trial
- Creators
- Benjamin D. PaceBrandon NeisewanderPatrick Ten EyckAaron D. BoesNicholas T. Trapp
- Resource Type
- Abstract
- Publication Details
- Brain stimulation, Vol.16(4), p.3
- DOI
- 10.1016/j.brs.2023.07.011
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Language
- English
- Date published
- 07/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics); Design Biostat and Ethics
- Record Identifier
- 9984458104202771
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