Abstract
Brain magnetic resonance imaging lesion volume correlates with physical disability and cognitive impairment in multiple sclerosis: comparison of 1.5T and 3T
Multiple sclerosis, Vol.14(1_Suppl.), pp.S257-S257
09/01/2008
Abstract
Background: There is growing interest in using higher field magnetic resonance imaging (MRI) to assess brain pathology in multiple sclerosis (MS). It is unknown if 3T improves clinical correlations compared to 1.5T MRI. Objective: To compare the relationship between brain lesions and clinical status in MS at 1.5T and 3T. Methods: 2D FLAIR was performed at 1.5T and 3T in 32 MS patients [1 clinically isolated syndrome; 26 relapsing-remitting, 5 primary or secondary progressive; Expanded Disability Status Scale (EDSS) (mean plus or minus SD) 2 plus or minus 1.9 (range 0-6.5), disease duration 8.18 plus or minus 7.4 (range 0.2-39) years]. MRI protocols were optimized and matched on voxel size. FLAIR lesions were quantified using a semi-automated edge finding tool with anonymous scan randomization. Cognitive testing was based on consensus panel standards emphasizing domains usually affected in MS. Results: Correlation between lesion volume and EDSS score was weak at l.ST (Spearman r=0.195, p>0.05) but significant at 3T (r=0.388, p=0.03). After accounting for age, sex, and depressive symptoms, associations were observed between 1.5T lesion volume and Brief Visuospatial Memory Test-Revised-Total Recall (BVMT-R-TR) (R2=0.417, p=0.01) and Symbol Digit Modalities Test (SDMT) (R2=0.549, p=0.001) and between 3T lesion volume and BVMT-R-TR (R2=0.383, p=0.03), SDMT (R2=0.699, p<0.00001), and Judgment of Line Orientation (R2=0.356, p=0.01). Other cognitive measures including Paced Auditory Serial Addition Test-3, Controlled Oral Word Association Test, and California Verbal Learning Test-II were not associated with lesion volume at 1.5T or 3T (p>0.05). Whole brain lesion volume was 22% higher at 3T on average (10,800 plus or minus 14,799mm3) than 1.5T (8,834 plus or minus 13,210mm3, p=0.01). Conclusions: 3T can demonstrate a higher brain lesion load and generally stronger associations with clinical status than 1.5T in MS. Higher field brain MRI may help improve clinical-MRI correlations in the monitoring of MS.
Details
- Title: Subtitle
- Brain magnetic resonance imaging lesion volume correlates with physical disability and cognitive impairment in multiple sclerosis: comparison of 1.5T and 3T
- Creators
- B GlanzJ StankiewiczB HealyR BenedictA AroraM NeemaZ GussG BuckleM HoutchensS KhouryH WeinerC GuttmannR Bakshi
- Resource Type
- Abstract
- Publication Details
- Multiple sclerosis, Vol.14(1_Suppl.), pp.S257-S257
- ISSN
- 1352-4585
- eISSN
- 1477-0970
- Comment
- Poster Presentations. Multiple Sclerosis Journal. 2008;14(1_suppl):29-293. doi:10.1177/1352458508096399
- Language
- English
- Date published
- 09/01/2008
- Academic Unit
- Psychiatry
- Record Identifier
- 9984631939002771
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