Abstract
Cardiorespiratory Coupling Response to Chest Wall Strapping in Chronic Obstructive Pulmonary Disease
The FASEB journal, Vol.36 Suppl 1(S1), p.n/a
05/2022
DOI: 10.1096/fasebj.2022.36.S1.R3081
PMID: 35554438
Abstract
Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by limited expiratory airflow due to lung destruction or airway obstruction. Chest wall strapping (CWS) is a potential therapy technique that restricts the upper abdomen, inducing breathing at lower lung volumes and opening small airways. Although the respiratory impacts of CWS have been examined, the relationship between CWS and the cardiovascular system, which is closely tied to ventilation, has not been well-established. Additionally, COPD patients have reduced autonomic nervous system activity, which may be reflected in cardiorespiratory coupling. Cardiorespiratory coupling causes increased heart rate during inhalation to accommodate for increased blood return. The strength of this relationship was evaluated during CWS in five COPD and six control patients by analyzing heart rate changes during ventilation cycles. Heart rate and ventilatory data were collected during baseline, CWS, and post-CWS removal periods. Average heart rate during each inhalation and exhalation was plotted against tidal volume, with the slope of the linear regression representing the strength of the cardiorespiratory coupling relationship (BPM/L). Multi-factor ANOVA statistics showed a significantly diminished strength in COPD patients compared to control (p < 0.001). There was no significant change in either group post-CWS, suggesting that the same-sized breaths will cause the heart to respond similarly regardless of the total lung capacity. A potential consequence of diminished cardiorespiratory coupling in COPD patients is strain on the right side of the heart, which then has to pump larger stroke volumes. Blunted cardiorespiratory coupling is not further impaired by CWS.
Details
- Title: Subtitle
- Cardiorespiratory Coupling Response to Chest Wall Strapping in Chronic Obstructive Pulmonary Disease
- Creators
- Maggie Peng - Scarsdale Public SchoolsIliya Amaza - University of Wisconsin–MadisonMichael Eberlein - University of IowaMelissa Bates - University of Iowa
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.36 Suppl 1(S1), p.n/a
- DOI
- 10.1096/fasebj.2022.36.S1.R3081
- PMID
- 35554438
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984288741602771
Metrics
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