Abstract
Cerebral Blood Flow Characteristics Responses Following Acute Aerobic Exercise in Individuals with and without Down Syndrome
The FASEB journal, Vol.32(S1), pp.712.7-712.7
04/2018
DOI: 10.1096/fasebj.2018.32.1_supplement.712.7
Abstract
Abstract only
Individuals with Down Syndrome (DS) commonly experience low to moderate levels of cognitive impairment and are at a high risk of developing dementia and Alzheimer's diseases (AD). Reduced cerebral blood flow (CBF) and altered CBF characteristics have been observed in the aging population without DS and has shown to have detrimental effects on cerebral microvasculature, which may increase the risk of developing dementia and AD. However, differences in CBF and its characteristics between individuals with and without DS and its response to exercise have not been studied.
Purpose
To examine the differences in CBF and its characteristics following a 20-minute bout of moderate intensity walking in individuals with and without DS.
Methods
Thirty-eight young (DS=19, Age=25 yrs) individuals with and without DS participated in this study. Changes in mean middle cerebral artery velocity (mMCAv), mMCAv characteristics (pulsatility index (PI), resistance index (RI)) and hemodynamic variables were measured before, immediately post and 30-minute post exericse.
Results
Baseline hemodynamics, systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), heart rate (HR) and mMCAv were not different between the DS and control group (p>0.05 for all). Neither group showed changes in mMCAv after moderate intensity treadmill walking exercise (p>0.05). However, the DS group exhibited significantly higher PI and RI at all time points when compared to controls (p<0.05 for both).
Conclusions
Our results demonstrate that CBF was not altered in individuals with DS at rest and following moderate intensity exercise and was not different from that of controls. However, higher PI and RI in DS group may be associated with reduced distal cerebral perfusion and microvascular damage in individuals with DS.
Details
- Title: Subtitle
- Cerebral Blood Flow Characteristics Responses Following Acute Aerobic Exercise in Individuals with and without Down Syndrome
- Creators
- SANG OUK Wee - California State University, San BernardinoElizabeth C. Schroeder - University of Illinois Urbana-ChampaignGeorgios Grigoriadis - University of Illinois Urbana-ChampaignKanokwan Bunsawat - University of UtahAlexander J. Rosenberg - University of Illinois Urbana-ChampaignGarett Griffith - University of Illinois Urbana-ChampaignTracy Baynard - University of Illinois Urbana-ChampaignBo Fernhall - University of Illinois Urbana-Champaign
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.32(S1), pp.712.7-712.7
- DOI
- 10.1096/fasebj.2018.32.1_supplement.712.7
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984958631602771
Metrics
1 Record Views