Abstract
Changes in aortic augmentation index following systemic β‐adrenergic blockade are dependent on heart rate
The FASEB journal, Vol.24(S1), pp.780.5-780.5
04/2010
DOI: 10.1096/fasebj.24.1_supplement.780.5
Abstract
We examined the effects of acute β‐adrenergic blockade on central artery hemodynamics and wave reflection characteristics in young healthy humans. High‐fidelity radial artery waveforms were recorded non‐invasively by applanation tonometry before and after intravenous propranolol (0.25 mg/kg bolus for 5 min followed by a maintenance infusion of 0.004/mg/kg/min for 20–30 min) in fourteen subjects (9 F/5M; 27 ± 2 years). Radial blood pressure (BP) was calibrated from the brachial BP (arterial catheter). Aortic augmentation index (AIa; a measure of amplitude and timing of arterial pressure wave reflection) and roundtrip travel time of the reflected wave to and from the periphery (Δtp; inverse of pulse wave velocity) were calculated from the generated aortic pressure waveform and are indices of central arterial stiffness. Systemic β‐blockade reduced heart rate (HR; 60 ± 2 vs. 53 ± 2 bpm, P < 0.001) and increased AIa (9.9 ± 4.3% vs. 4.3 ± 4.4%, P < 0.05), but did not alter Δtp (156 ± 4 msec vs. 152 ± 2 msec, P = 0.34). The AIa normalized to a HR of 75bpm (AIa@75) was not increased following β‐blockade (P = 0.67). Taken together, our data indicate that the increase in AIa following systemic β‐blockade is a result of a slower HR and not due to changes in β‐ mediated vascular tone.
Supported by NIH K23 DK‐082424 (TBC), AHA 2170087(ECH) and CTSA RR‐024150
Details
- Title: Subtitle
- Changes in aortic augmentation index following systemic β‐adrenergic blockade are dependent on heart rate
- Creators
- Alexander R Allen - Mayo ClinicTimothy B. Curry - Mayo Clinic in FloridaEmma C. Hart - Mayo ClinicNisha Charkoudian - Mayo Clinic in FloridaMichael J. Joyner - Mayo ClinicDarren P. Casey - Mayo Clinic in Florida
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.24(S1), pp.780.5-780.5
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.780.5
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- AHA (2170087) CTSA (RR‐024150) NIH (K23 DK‐082424)
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294929202771
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