Abstract
Characteristics of airflow and particle deposition in COPD current smokers
Bulletin of the American Physical Society, Vol.62(14), L4.00010
Annual Meeting of the APS Division of Fluid Dynamics, 70th (Denver, Colorado, 11/19/2017 - 11/21/2017)
11/2017
Abstract
A recent imaging-based cluster analysis of computed tomography (CT) lung images in a chronic obstructive pulmonary disease (COPD) cohort identified four clusters, viz. disease sub-populations. Cluster 1 had relatively normal airway structures; Cluster 2 had wall thickening; Cluster 3 exhibited decreased wall thickness and luminal narrowing; Cluster 4 had a significant decrease of luminal diameter and a significant reduction of lung deformation, thus having relatively low pulmonary functions. To better understand the characteristics of airflow and particle deposition in these clusters, we performed computational fluid and particle dynamics analyses on representative cluster patients and healthy controls using CT-based airway models and subject-specific 3D-1D coupled boundary conditions. The results show that particle deposition in central airways of cluster 4 patients was noticeably increased especially with increasing particle size despite reduced vital capacity as compared to other clusters and healthy controls. This may be attributable in part to significant airway constriction in cluster 4. This study demonstrates the potential application of cluster-guided CFD analysis in disease populations.
Details
- Title: Subtitle
- Characteristics of airflow and particle deposition in COPD current smokers
- Creators
- Chunrui Zou - University of IowaBabak HaghighiSanghun Choi - University of IowaEric A Hoffman - University of Iowa, RadiologyChing-Long Lin - University of Iowa, Mechanical Engineering
- Resource Type
- Abstract
- Publication Details
- Bulletin of the American Physical Society, Vol.62(14), L4.00010
- Conference
- Annual Meeting of the APS Division of Fluid Dynamics, 70th (Denver, Colorado, 11/19/2017 - 11/21/2017)
- Publisher
- American Physical Society
- ISSN
- 0003-0503
- Grant note
- NIH grants U01HL114494 and S10-RR022421, and FDA grant U01FD005837
- Language
- English
- Date published
- 11/2017
- Academic Unit
- Chemical and Biochemical Engineering; Internal Medicine; Radiology; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984571659202771
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