Abstract
Circulating lipids and lipoproteins and coagulation and fibrinolytic factors do not change in response to soy protein intake in perimenopausal women
The Journal of nutrition, Vol.132(3), p.607
03/01/2002
Abstract
Soy protein favorably alters serum lipids and lipoproteins in hypercholesterolemic individuals, thereby reducing cardiovascular disease risk. Our primary purpose was to determine the effect of soy protein (40 g/d) on circulating lipids, lipoproteins, and coagulation and fibrinolytic factors in normocholesterolemic and mildly hypercholesterolemic perimenopausal women. We also determined the contribution of coagulation, fibrinolytic, and other factors (e.g., body size and composition; serum estrogens, ferritin, and iron; dietary intake) to lipid profiles. Subjects were randomly assigned to treatment with isoflavone-rich soy (n = 24), isoflavone-poor soy (n = 24), or whey control (n = 21) protein. We measured circulating lipids and lipoproteins at baseline, week 12, and week 24 and coagulation and fibrinolytic factors at baseline and week 24. Coagulation and fibrinolytic factors were not adversely affected by treatment, as often occurs with estrogen or hormone replacement therapy. Treatment did not alter lipid profiles in mildly hypercholesterolemic subjects (n = 30) or in all subjects combined. Time had a significant (P < 0.001) effect on serum total cholesterol, triacylglycerol, LDL cholesterol, and HDL cholesterol concentrations. We could not attribute changes over time to various factors but at baseline accounted for 57% of the variability in HDL cholesterol (P < 0.0001) and for 50% in the total-HDL cholesterol ratio (P < 0.0001). Dietary vitamin E and percent energy from fat had positive effects whereas plasma plasminogen activator inhibitor-l, fibrinogen, body weight, and serum ferritin had negative effects on HDL and total-HDL cholesterol ratio. Isoflavone-rich or isoflavone-poor soy protein had no effect on lipid profiles or coagulation and fibrinolytic factors, whereas the effect of time suggested that the hormonal milieu during the menopausal transition may have overridden any detectable treatment effect on lipids. The relationship between coagulation factors and serum lipids should be further examined as indexes of cardiovascular disease risk in midlife women (1).
Details
- Title: Subtitle
- Circulating lipids and lipoproteins and coagulation and fibrinolytic factors do not change in response to soy protein intake in perimenopausal women
- Creators
- D. Lee AlekelSarah B DentCharles T PetersonLarry D BraceJames H SwainManju B ReddyKathy B HansonJennifer G Robinson
- Resource Type
- Abstract
- Publication Details
- The Journal of nutrition, Vol.132(3), p.607
- Publisher
- American Institute of Nutrition
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Comment
- Poster Abstracts, The Journal of Nutrition, Volume 132, Issue 3, 2002, Pages 588S-619S, ISSN 0022-3166, https://doi.org/10.1093/jn/132.3.588S.
- Language
- English
- Date published
- 03/01/2002
- Description audience
- Academic; Professional
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364535902771
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