Abstract
Classification of lung function trajectories in SPIROMICS
European respiratory journal, Vol.58(Suppl. 65), p.PA1858
09/05/2021
DOI: 10.1183/13993003.congress-2021.pa1858
Abstract
Introduction/Background: The clinical course of chronic obstructive pulmonary disease (COPD) ranges from rapid decline to stability/improvement in FEV1.
Aims/Objectives: To identify clinical characteristics of subjects enrolled in the longitudinal COPD study SPIROMICS associated with divergent rates of change in post-bronchodilator FEV1.
Methods: Current or former smokers, GOLD stage 0-4, with ≥20 pack-year smoking history were included in the analysis and followed up to 8 years. Non-smoking subjects with normal pulmonary function and subjects with missing slope data were eliminated. Subjects were classified by change in post-bronchodilator FEV1 as rapid decliners RD (≥-100 ml/year, n=449), decliners D (-1 to -99 ml/year, n=1246) or stable/improvers S/I (≥0 ml/year, n=580).
Results: Distribution of the three groups across GOLD stages was similar. No clinically meaningful differences between the three groups (RD, D, S/I) in age (62, 64, 63 years), BMI, race, asthma history (21%, 20%, 20%), pack-years of smoking (50, 49, 49), emphysema on CT scan at TLC (7.3, 7.5, 7.4 % voxels <-950 HU) or occurrence of exacerbations (24, 25%, 25%) were observed. RD had better baseline post-bronchodilator FEV1 and FVC compared with D and S/I (FEV1 2.35, 2.08, 2.02 L; FVC 3.82, 3.39, 3.31 L (P<0.0001 for all four comparisons). 47% of RD were current smokers compared with 36% of D and 36% of S/I.
Conclusion: In SPIROMICS, most clinical characteristics did not distinguish between different trajectories of lung function over time. Rapid decliners had better lung function at baseline and were more likely to be current smokers. However, 36% of current smokers had stable or improved lung function demonstrating relative resilience against progression of COPD.
Details
- Title: Subtitle
- Classification of lung function trajectories in SPIROMICS
- Creators
- Wayne Anderson - University of North Carolina at Chapel HillMiguel Quibrera - University of North Carolina at Chapel HillDavid Couper - University of North Carolina at Chapel HillMehrdada ArjomandiIgor Barjaktarevic - University of California, Los AngelesGraham Barr - Columbia UniversitySurya P. Bhatt - University of Alabama at BirminghamMark T. Dransfield - University of Alabama at BirminghamBradley Drummond - University of North Carolina at Chapel HillMeiLan K. Han - University of Michigan–Ann ArborNadia N. Hansel - Johns Hopkins UniversityAnnette T. Hastie - Wake Forest UniversityEric A. Hoffman - University of IowaRichard E. Kanner - University of UtahVictor Kim - Temple UniversityStephen C. LazarusVictor E. Ortega - Wake Forest UniversityRobert PaineStephen I. Rennard - University of Nebraska at OmahaDonald P. Tashkin - University of California, Los AngelesPrescott G. Woodruff - University of California, San FranciscoChristopher J. Cooper - University of California, Los Angeles
- Resource Type
- Abstract
- Publication Details
- European respiratory journal, Vol.58(Suppl. 65), p.PA1858
- Publisher
- European Respiratory Society
- DOI
- 10.1183/13993003.congress-2021.pa1858
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Language
- English
- Date published
- 09/05/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Internal Medicine; Radiology
- Record Identifier
- 9984528099702771
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