Abstract
Cluster-specific small airway modeling for imaging-based CFD analysis of pulmonary air flow and particle deposition in COPD smokers
Bulletin of the American Physical Society, Vol.62(14), BAPS.2017.DFD.L4.11
Annual Meeting of the APS Division of Fluid Dynamics, 70th (Denver, Colorado, 11/19/2017 - 11/21/2017)
2017
Abstract
Accurate modeling of small airway diameters in patients with chronic obstructive pulmonary disease (COPD) is a crucial step toward patient-specific CFD simulations of regional airflow and particle transport. We proposed to use computed tomography (CT) imaging-based cluster membership to identify structural characteristics of airways in each cluster and use them to develop cluster-specific airway diameter models. We analyzed 284 COPD smokers with airflow limitation, and 69 healthy controls. We used multiscale imaging-based cluster analysis (MICA) to classify smokers into 4 clusters. With representative cluster patients and healthy controls, we performed multiple regressions to quantify variation of airway diameters by generation as well as by cluster. The cluster 2 and 4 showed more diameter decrease as generation increases than other clusters. The cluster 4 had more rapid decreases of airway diameters in the upper lobes, while cluster 2 in the lower lobes. We then used these regression models to estimate airway diameters in CT unresolved regions to obtain pressure-volume hysteresis curves using a 1D resistance model. These 1D flow solutions can be used to provide the patient-specific boundary conditions for 3D CFD simulations in COPD patients.
Details
- Title: Subtitle
- Cluster-specific small airway modeling for imaging-based CFD analysis of pulmonary air flow and particle deposition in COPD smokers
- Creators
- Babak HaghighiJiwoong Choi - University of Iowa, Mechanical EngineeringSanghun Choi - Kyungpook National UniversityEric A Hoffman - University of Iowa, RadiologyChing-Long Lin - University of Iowa, Mechanical Engineering
- Resource Type
- Abstract
- Publication Details
- Bulletin of the American Physical Society, Vol.62(14), BAPS.2017.DFD.L4.11
- Conference
- Annual Meeting of the APS Division of Fluid Dynamics, 70th (Denver, Colorado, 11/19/2017 - 11/21/2017)
- Publisher
- American Physical Society
- ISSN
- 0003-0503
- Grant note
- Support for this study was provided, in part, by NIH grants U01-HL114494, R01-HL112986 and S10-RR022421.
- Language
- English
- Date published
- 2017
- Academic Unit
- Internal Medicine; Mechanical Engineering; Radiology; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984571659102771
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