Abstract
Combined Liver-Kidney Transplant in Children: SA-PO684
Journal of the American Society of Nephrology, Vol.35(10S)
10/2024
DOI: 10.1681/ASN.20245kxjjbyb
Abstract
Background:
Data describing outcomes of pediatric combined liver-kidney transplant (CLKT) are limited.
Methods:
Retrospective cohort study of pediatric CLKT, liver-alone transplants (LT), and kidney-alone transplants (KT) in US from 1/1/2001 to 12/31/2019 using SRTR data. Primary outcomes include demographic and clinical characteristics, graft, and patient survival.
Results:
There were 284 CLKT recipients with a median age of 10 yrs; 22.5% had polycystic kidney disease and 18.7% had primary hyperoxaluria (Table 1). CLKT recipients were more likely to have a history of prior transplant, be listed at multiple centers, and be on dialysis prior to CLKT. CLKT were more likely to receive a whole liver and be listed with exception points compared to LT. CLKT were more likely to have en bloc kidney transplants, KDPI 35-85% donor kidneys, and DGF compared to KT. CLKT graft survival was superior to LT but inferior to KT long term (Fig 1). CLKT patient survival was inferior to KT but similar to LT.
Conclusion:
CLKT recipients have different transplant characteristics and outcomes compared to LT or KT alone recipients. Further research is needed to understand the factors driving these differences.
Details
- Title: Subtitle
- Combined Liver-Kidney Transplant in Children: SA-PO684
- Creators
- Amber Jasmine Kazi - Seattle Children's HospitalJuhi Kumar - Children's Hospital of PittsburghJodi M. Smith - Seattle Children's HospitalNicole A. Hayde - Montefiore Medical CenterLyndsay Harshman - University of IowaChloe E. Douglas - Seattle Children's HospitalSarah J. Kizilbash - University of MinnesotaSharon M. Bartosh - University of Wisconsin–MadisonRachel M. Engen - University of Wisconsin–Madison
- Resource Type
- Abstract
- Publication Details
- Journal of the American Society of Nephrology, Vol.35(10S)
- Publisher
- AMER SOC NEPHROLOGY
- DOI
- 10.1681/ASN.20245kxjjbyb
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Language
- English
- Date published
- 10/2024
- Academic Unit
- Nephrology, Dialysis and Transplantation; Iowa Neuroscience Institute; Radiation Oncology; Stead Family Department of Pediatrics
- Record Identifier
- 9984740957102771
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