Abstract
Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - a retrospective longitudinal cohort multicenter study
Oral surgery, oral medicine, oral pathology and oral radiology, Vol.140(3), p.e112
09/2025
DOI: 10.1016/j.oooo.2025.04.138
Abstract
Introduction
Glandular odontogenic cyst (GOC) is an uncommon developmental odontogenic cyst with a peak incidence in the 4th decade and a predilection for the anterior mandible. GOCs exhibit a variable microscopic appearance, and the diagnosis can be established based on specific microscopic criteria. This is a multi-institutional study that investigates factors associated with GOC recurrence.
Methods
Patients with a histologically confirmed GOC, as determined by fulfilling at least 7 of the 10 diagnostic criteria per Fowler et al., who experienced a recurrence after at least one year following treatment were included. GOCs with at least five years of follow-up without recurrence were used as controls. The histologic features, treatment rendered, and immunohistochemical staining with CK13, CK19, and Ki-67 were documented.
Results
Of the eleven recurrent cases, six occurred in males and five in females (mean age of 56.09 years). The anterior mandible was the most frequently affected site (45.5% of cases), followed by the posterior and anterior maxilla (27.1%, each). The average follow-up was 36.1 months. Chi-square analysis revealed that multiple compartments and the absence of apocrine snouting were significantly associated with recurrence (p =0.013 and p = 0.034, respectively). Interestingly, CK13 showed strong patchy staining in the primary GOCs and negative immunostaining in their recurrences (p ≤0.05) and for the non-recurrent cases (p =0.34). No differences were observed with remaining stains. The majority of the recurrent GOCs were treated by enucleation (73% of cases).
Conclusion
Our study showed the presence of multiple compartments and the absence of apocrine snouting are important predictors for GOC recurrence. In addition, enucleation alone may be associated with higher recurrence rates. We propose a secondary procedure, such as peripheral osteotomy with 5mm clear margins or adjunctive therapy with 5-FU may represent a promising therapeutic approach for reducing GOC recurrences.
Details
- Title: Subtitle
- Comparative study of the clinicopathologic characteristics and immunohistochemical expression of recurrent and non-recurrent glandular odontogenic cysts - a retrospective longitudinal cohort multicenter study
- Creators
- Alberto Peraza Labrador - Texas A&M UniversityJohn Wright - Texas A&M UniversityVictoria Woo - Texas A&M UniversityMonica Kowalski - Columbia UniversityKittiphoj Tikkhanarak - University of IowaNidhi Handoo - University of IowaWattawan Wongpattaraworakul - University of IowaElizabeth BilodeouFelipe Nor - University of Michigan–Ann ArborMolly Housley Smith - University of KentuckyMatthew Kesterke - Texas A&M UniversityPatricia Barros - Nova Southeastern UniversityMadhu Shrestha - Texas A&M University
- Resource Type
- Abstract
- Publication Details
- Oral surgery, oral medicine, oral pathology and oral radiology, Vol.140(3), p.e112
- DOI
- 10.1016/j.oooo.2025.04.138
- ISSN
- 2212-4403
- Language
- English
- Date published
- 09/2025
- Academic Unit
- Oral Pathology, Radiology and Medicine
- Record Identifier
- 9984865444802771
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