Abstract
Computed Tomography Cluster-informed Subject-Specific Assessment of Airway Resistance and Particle Deposition in Post-COVID-19 Lungs
Bulletin of the American Physical Society, Vol.67(19)
Annual Meeting of the American Physical Society (APS) Division of Fluid Dynamics (DFD), 75th (11/20/2022 - 11/22/2022)
2022
Abstract
Patients who recovered from the severe acute respiratory syndrome coronavirus (SARS-CoV-2 or COVID-19) may have long-term symptoms, given the diagnosis long COVID or post-acute sequelae of COVID-19 (PASC). In this study, we employed a cluster-informed (or guided) strategy that utilized contrastive learning and K-means to identify post-COVID-19 clusters from computed tomography (CT) images, and applied a CT imaging-based subject-specific multi-scale whole-lung computational fluid and particle dynamics (CFPD) model to investigate fluid dynamics within clusters for assessment of disease risk or therapeutic response. 140 post-COVID-19 subjects and 105 healthy controls were analyzed. The average time between COVID-19 diagnosis and CT acquisition was 113 days. Two clusters were identified, characterized by small airways disease (cluster 1, C1) and fibrotic-like lung patterns (cluster 2, C2), respectively. C1 had increased lobar resistance during tidal breathing due to airway narrowing, while C2 exhibited decreased lobar resistance due to airway-associated interstitial lungs. Compared to healthy controls, the whole-lung deposition in C2 during tidal breathing was reduced by 2% (p < 0.05) for particles ranging from 0.01 to 10.0 μm.
Details
- Title: Subtitle
- Computed Tomography Cluster-informed Subject-Specific Assessment of Airway Resistance and Particle Deposition in Post-COVID-19 Lungs
- Creators
- Xuan ZhangFrank LiPrathish K. RajaramanA. P. ComellasEric A HoffmanChinglong Lin - Mechanical Engineering
- Resource Type
- Abstract
- Publication Details
- Bulletin of the American Physical Society, Vol.67(19)
- Conference
- Annual Meeting of the American Physical Society (APS) Division of Fluid Dynamics (DFD), 75th (11/20/2022 - 11/22/2022)
- Publisher
- Indianapolis, Indiana
- ISSN
- 0003-0503
- Alternative title
- 75th Annual Meeting of the Division of Fluid Dynamics
- Language
- English
- Date published
- 2022
- Academic Unit
- ICTS; IIHR--Hydroscience and Engineering; Internal Medicine; Mechanical Engineering; Pulmonary, Critical Care, and Occupational Medicine; Radiology; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984567874702771
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