Abstract
DIABETES AND OUTCOME OF PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION LESIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Journal of the American College of Cardiology, Vol.71(11 Supplement), pp.A1060-A1060
03/10/2018
DOI: 10.1016/S0735-1097(18)31601-2
Abstract
Background
Diabetes Mellitus (DM) was known to increase mortality and restenosis in patients undergoing percutaneous intervention (PCI). Recent studies suggest that DM is associated with unfavorable outcome in chronic total occlusion (CTO) patients undergoing PCI. However, a systematic review and meta-analysis of the literature have not been done. We assessed the outcome of PCI in CTO patients with and without diabetes.
Methods
We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Included studies were published cohort (prospective or retrospective) studies that reported major cardiac events (MACE), including cardiac death, target vessel revascularization, myocardial infarction, and stroke in CTO patients with and without DM whom underwent PCI. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate risk ratios and 95% confidence intervals.
Results
Nine studies from 2011 to 2017 were included in this meta-analysis involving 7,894 subjects with CTO lesion who underwent PCI (2,624 DM and 5,270 non-DM). DM was not significantly associated with increased risk of MACE (pooled risk ratio=1.23, 95 % confidence interval: 0.91-1.65, p=0.19, I2=86.1%) (Figure 1).
Conclusion
Our study suggests that DM did not significantly increase risk of MACE in CTO patients whom underwent PCI.
Details
- Title: Subtitle
- DIABETES AND OUTCOME OF PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION LESIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS
- Creators
- Wasawat Vutthikraivit - Texas Tech University Health Sciences CenterPavida Pachariyanon - Texas Tech University Health Sciences CenterSaranapoom Klomjit - Texas Tech University Health Sciences CenterPattara Rattanawong - Texas Tech University Health Sciences CenterPakpoom Tantrachoti - Texas Tech University Health Sciences CenterAwapa Prombandankul - Texas Tech UniversityWeera Sukhumthammarat - Texas Tech University Health Sciences CenterPrapaipan Putthapiban - Texas Tech University Health Sciences CenterMohammad Ansari - Texas Tech University
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.71(11 Supplement), pp.A1060-A1060
- Publisher
- ELSEVIER SCIENCE INC
- DOI
- 10.1016/S0735-1097(18)31601-2
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Language
- English
- Date published
- 03/10/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695661902771
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