DRUG-COATED BALLOON VERSUS DRUG-ELUTING STENT IN SMALL VESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Wasawat Vutthikraivit; Pattara Rattanawong; Prapaipan Putthapiban; Pavida Pachariyanon; Genanew Bedanie; Kanak Parmar; Elias Hanna

doi:10.1016/S0735-1097(21)02409-8

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DRUG-COATED BALLOON VERSUS DRUG-ELUTING STENT IN SMALL VESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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DRUG-COATED BALLOON VERSUS DRUG-ELUTING STENT IN SMALL VESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Wasawat Vutthikraivit, Pattara Rattanawong, Prapaipan Putthapiban, Pavida Pachariyanon, Genanew Bedanie, Kanak Parmar and Elias Hanna

Journal of the American College of Cardiology, Vol.77(18 Supplement 1), pp.1050-1050

05/11/2021

DOI: 10.1016/S0735-1097(21)02409-8

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Abstract

Background Revascularization of small vessel coronary artery disease (SvCAD) is still challenging despite the extensive use of drug-eluting stents (DESs), mainly because of an increase in target vessel failure. Drug-coated balloon (DCB) has emerged as an alternative strategy in SvCAD. However, the safety and efficacy of DCB in SvCAD is still controversial. We conducted a meta-analysis comparing the clinical outcomes of DCB and DES in SvCAD patients. Methods We comprehensively searched the databases of MEDLINE and EMBASE from inception to December 2020. Included studies were published randomized control trials (RCTs) that compared major adverse cardiac events (MACE), target-lesion revascularization (TLR), and target-vessel revascularization (TVR) between DCB and DES in SvCAD patients. Data from each study were combined using the random-effects model. Results Four RCTs were included in this meta-analysis involving 1,227 SvCAD patients (616 underwent revascularization with DCB and 611 with DES). There was no difference in MACE, TLR, and TVR between DCB and DES groups ([OR] 0.99, 95% CI 0.51-1.90, I2=55.5%, p=0.965, [OR] 1.41, 95% CI 0.41-4.88, I2=63.2%, p=0.584, and [OR] 0.88, 95% CI 0.48-1.62, I2=36.3%, p=0.684, respectively) (Figure 1). There was no publication bias observed in Funnel plot. Conclusion As compared to DES, our study showed that DCB was associated with similar clinical outcomes and could be a potential alternative strategy in SvCAD patients.

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Title: Subtitle: DRUG-COATED BALLOON VERSUS DRUG-ELUTING STENT IN SMALL VESSEL CORONARY ARTERY DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Creators: Wasawat Vutthikraivit - University of Iowa
Pattara Rattanawong - University of Iowa
Prapaipan Putthapiban - University of Iowa
Pavida Pachariyanon - University of Iowa
Genanew Bedanie - University of Iowa
Kanak Parmar - University of Iowa
Elias Hanna - University of Iowa
Resource Type: Abstract
Publication Details: Journal of the American College of Cardiology, Vol.77(18 Supplement 1), pp.1050-1050
DOI: 10.1016/S0735-1097(21)02409-8
ISSN: 0735-1097
eISSN: 1558-3597
Language: English
Date published: 05/11/2021
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984695662702771

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