Abstract
Effect of Age and Acute Exercise on Circulating Endostatin
The FASEB journal, Vol.32(S1), pp.lb253-lb253
04/2018
DOI: 10.1096/fasebj.2018.32.1_supplement.lb253
Abstract
BACKGROUND
Endostatin may have both angiogenic and angiostatic effects in vivo, although angiostatic effects appear to predominate. It has been reported that circulating levels of endostatin increase after acute exercise in young adults; however, it is unclear whether healthy older adults exhibit a similar response.
PURPOSE
The purpose of this study was to determine the effect of age on changes in serum endostatin concentration following an acute bout of dynamic exercise.
METHODS
Ten young (25 ± 1 years, 5M/5F) and nine older (68 ± 2 years, 4M, 5F) healthy but sedentary to recreationally active adults completed a single 45‐minute bout of submaximal cycle ergometer exercise at 60 – 65% of their age‐predicted maximal heart rate. Venous blood samples were obtained prior to (PREX), immediately post‐ (POSTX0), and at three hours post‐exercise (POSTX3). Serum concentrations of endostatin were analyzed at each time point using an enzyme‐linked immunosorbent assay. Absolute protein concentrations at each time point and fold‐change from PREX concentrations are reported.
RESULTS
There was no difference in PREX serum endostatin concentration between young (136.2 ± 18.48 pg/mL) and older adults (125.9 ± 11.48 pg/mL) (p=0.81). Additionally, there was no age effect on absolute endostatin concentrations at POSTX0 and POSTX3 (p = 0.06 for interaction). However, when comparing the fold‐change in endostatin concentration after exercise, there was a significant interaction (p = 0.01) between age and POSTX0 to POSTX3 time point. The main effects (time, age) were not significant. Simple main effects analysis revealed a difference in fold‐change in concentration of endostatin from PREX in older (p = 0.02) but not younger (p = 0.80) adults from POSTX0 to POSTX3.
CONCLUSIONS
Our data suggests there is no difference in either PREX serum endostatin concentrations between young and older adults. However, older adults may have a different temporal response in serum endostatin following a single bout of moderate intensity dynamic exercise compared to young adults.
Support or Funding Information
Research Support: University of Iowa Carver College of Medicine FUTURE in Biomedicine Program (MJL, BRM, DPC).
This is from the Experimental Biology 2018 Meeting. There is no full text article associated with this published in The FASEB Journal.
Details
- Title: Subtitle
- Effect of Age and Acute Exercise on Circulating Endostatin
- Creators
- McKenzie K. Temperley - Drake UniversityBenjamin R. Mardis - Drake UniversityErika Iwamoto - University of IowaJoshua M Bock - University of IowaDarren P. Casey - University of IowaMeredith Luttrell - Drake University
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.32(S1), pp.lb253-lb253
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.2018.32.1_supplement.lb253
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- University of Iowa Carver College of Medicine FUTURE in Biomedicine Program
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294933502771
Metrics
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