Abstract
Effect of combined inhibition of adenosine and nitric oxide on compensatory vasodilation during exercise with acute hypoperfusion
The FASEB journal, Vol.24(S1), pp.804.10-804.10
04/2010
DOI: 10.1096/fasebj.24.1_supplement.804.10
Abstract
Nitric oxide (NO) contributes to compensatory vasodilation in the contracting human forearm subjected to hypoperfusion during exercise. We tested the potential for adenosine/NO interaction in the compensatory dilation. Eight males (25 ± 2 yrs) performed forearm exercise (20% of max) during intra‐arterial balloon inflation. Each trial included; exercise, exercise with balloon inflation, and exercise after deflation (3 min each). Forearm blood flow (FBF; ultrasound) and brachial artery catheter pressure (BAP) were measured. Exercise was repeated during NO synthase inhibition (L‐NMMA) alone and with the combination of L‐NMMA/aminophylline (adenosine receptor blockade). Forearm vascular conductance (FVC; ml/min/100mmHg) was calculated from BF (ml/min) and BAP (mmHg). The % recovery in FVC during inflation was calculated as (steady state inflation plus exercise value – nadir)/[steady state exercise (control) value‐nadir]. FVC fell acutely with balloon inflation during all trials (P < 0.01). During the control trial, the % recovery in FVC was 111 ± 8%. The % recovery in FVC was attenuated with NOS inhibition alone (80 ± 9%; P < 0.001 vs. control) and attenuated further with combined inhibition of NO/adenosine (63 ± 9%; P < 0.05 vs. L‐NMMA). Thus, adenosine has an NO independent role in the compensatory vasodilatation during exercise with acute hypoperfusion.
NIH HL46493 (MJJ), AR55819 (DPC) and RR‐024150.
Details
- Title: Subtitle
- Effect of combined inhibition of adenosine and nitric oxide on compensatory vasodilation during exercise with acute hypoperfusion
- Creators
- Darren P. Casey - Mayo Clinic in FloridaBranton G. Walker - Mayo ClinicShelly K. Roberts - Mayo ClinicJean N. Knutson - Mayo ClinicMichael J. Joyner - Mayo Clinic
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.24(S1), pp.804.10-804.10
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.804.10
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984295038202771
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