Abstract
Effect of physical activity (PA) before and after diagnosis on overall survival (OS) for patients (pts) with lymphoma
Journal of clinical oncology, Vol.36(7_suppl), pp.95-95
03/01/2018
DOI: 10.1200/JCO.2018.36.7_suppl.95
Abstract
95
Background: While PA is known to improve quality of life in lymphoma pts, its impact on OS is not known. We studied the effect of PA on OS in lymphoma pts enrolled at diagnosis in the Iowa/Mayo Molecular Epidemiology Resource. Methods: Godin Leisure Score Index (LSI; Range 0-50) was calculated based on level of PA pre-diagnosis (baseline) and 3 years post diagnosis (FU3), with pts grouped by tertile into high, moderate, or low PA. At FU3, pts also reported perceived change in PA since diagnosis. OS was measured as time from assessment (baseline or FU3) until death from any cause. Associations between LSI tertiles and OS were assessed using Cox models adjusted for lymphoma subtype, age and sex. Results: PA level was available for 3060 pts at baseline and 1371 pts at FU3. 95% had an ECOG performance status < 2, 37% had an aggressive subtype, 29% had BMI ≥ 30, and 54% were age > 60. Indolent lymphoma pts with higher PA at baseline had no difference in OS. Higher PA at FU3 had improved OS (moderate vs low HR 0.63, CI 0.42-0.93; high vs low HR 0.53, CI 0.33-0.86). Pts with BMI < 30 who had higher PA at baseline showed no difference in OS. Higher PA at FU3 had improved OS for pts with BMI < 30 (moderate vs low HR 0.68 CI, 0.48-0.98; high vs low HR = 0.41, CI 0.26-0.64). For pts > 60 years, high vs low baseline PA showed improved OS (HR 0.77, CI 0.63-0.93). Higher PA at FU3 (moderate vs low HR 0.68 CI 0.48-0.96, high vs low HR 0.53 CI 0.34-0.83) was associated with OS. At FU3, compared to no change, perceived reduction of PA was associated with worse OS for indolent lymphoma (HR 2.13, CI 1.56-2.91), BMI < 30 (HR 1.95, CI 1.45-2.62), BMI > 30 (HR 2.00, CI 1.21-3.30), age ≤ 60 (HR 3.06, CI 1.72-5.46), and age > 60 (HR 1.98, CI 1.52-2.58). Perceived increase in PA was not associated with OS. Higher PA in pts with aggressive lymphoma, BMI ≥30, and age < 60 was not significantly associated with OS but trended similarly. All results were similar when analyzing by continuous LSI score. Conclusions: Higher levels of PA, especially at FU3, were associated with superior OS. The effect was more pronounced in pts with indolent lymphoma, BMI < 30, or age > 60. Perceived reduction in PA was associated with worse outcomes. PA should be incorporated into lymphoma survivorship plans.
Details
- Title: Subtitle
- Effect of physical activity (PA) before and after diagnosis on overall survival (OS) for patients (pts) with lymphoma
- Creators
- Andrew Ip - Piedmont Cancer InstitutePriyanka Avinash Pophali - Mayo ClinicMelissa C. Larson - Mayo ClinicAllison Claire Rosenthal - Mayo Clinic HospitalMatthew John Maurer - Mayo ClinicBrian K. Link - University of IowaUmar Farooq - University of IowaAndew L. Feldman - Mayo Clinic Rochester, MNCristine Allmer - Mayo Clinic in FloridaSusan L. Slager - Mayo ClinicThomas Matthew Habermann - Mayo ClinicChristopher Flowers - Piedmont Cancer InstituteJames Robert Cerhan - Mayo ClinicJonathon Brett Cohen - Piedmont Cancer InstituteCarrie A. Thompson - Mayo Clinic
- Resource Type
- Abstract
- Publication Details
- Journal of clinical oncology, Vol.36(7_suppl), pp.95-95
- DOI
- 10.1200/JCO.2018.36.7_suppl.95
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Epidemiology; Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984362353502771
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