Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Adam W. Mailloux; Pearlie K. Epling-Burnette

doi:10.4161/onci.22654

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Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Abstract

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Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Adam W. Mailloux and Pearlie K. Epling-Burnette

Oncoimmunology, Vol.2(2), pp.e22654-e22654

02/01/2013

DOI: 10.4161/onci.22654

PMCID: PMC3601152

PMID: 23524348

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Abstract

Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.

Author's View

immune escape

immunoediting

leukemia

myelodysplastic syndrome

regulatory T cells

Details

Title: Subtitle: Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
Creators: Adam W. Mailloux - Moffitt Cancer Center
Pearlie K. Epling-Burnette - Moffitt Cancer Center
Resource Type: Abstract
Publication Details: Oncoimmunology, Vol.2(2), pp.e22654-e22654
DOI: 10.4161/onci.22654
PMID: 23524348
PMCID: PMC3601152
NLM abbreviation: Oncoimmunology
ISSN: 2162-4011
eISSN: 2162-402X
Publisher: Landes Bioscience
Language: English
Date published: 02/01/2013
Academic Unit: Microbiology and Immunology
Record Identifier: 9984297637502771

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