Abstract
Effects of ambient temperature on COPD symptoms and exacerbations in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) cohort
European respiratory journal, Vol.58(Suppl. 65), p.OA103
09/05/2021
DOI: 10.1183/13993003.congress-2021.oa103
Abstract
Heat exposures have been associated with increased respiratory mortality in patients with COPD, and there is concern that this problem will accelerate with a warming climate. We examined the association between risk of COPD exacerbations and ambient temperature in preceding days in a well-characterized cohort.
We conducted a time-stratified case-crossover analysis of 1177 current and former smokers from SPIROMICS with at least one COPD exacerbation since study enrollment. Using conditional logistic regression, with local ambient temperature as a continuous variable, we assessed the risk of COPD exacerbation based on ambient temperature at lag days 0 to 7.
Mean age of participants was 63.7 years [SD 8.6]) and mean time to first exacerbation was 603 days [SD 523]. The risk of exacerbation was elevated for increased temperatures during the preceding one to six days, with the observed risk peaking at the two-day lag period. After controlling for relative humidity, each one-degree Celsius increase in ambient temperature was significantly associated with 2% increased odds of COPD exacerbation two days following the elevated temperature (p=0.002, Figure 1).
These findings suggest an increased risk of COPD exacerbations approximately 2 days following an increase in ambient temperature, raising concern for increased exacerbation risk with a changing climate.
Details
- Title: Subtitle
- Effects of ambient temperature on COPD symptoms and exacerbations in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) cohort
- Creators
- Supaksh Gupta - University of WashingtonCoralynn Sack - University of WashingtonLaura M. Paulin - Dartmouth–Hitchcock Medical CenterAmanda J. Gassett - University of WashingtonClifford Sung - University of WashingtonJeremy J. Hess - University of WashingtonPrescott G. Woodruff - University of California, San FranciscoMark T. Dransfield - University of Alabama at BirminghamRobert Paine - University of UtahIgor Barjaktarevic - University of California, Los AngelesAlejandro P. Comellas - University of IowaMaryam Karimi - University of Alabama at BirminghamCheryl S. Pirozzi - University of UtahVictor E. Ortega - Wake Forest UniversityWassim W. Labaki - University of MichiganSurya P. Bhatt - University of Alabama at BirminghamNadia N. Hansel - Johns Hopkins UniversityJoel D. Kaufman - University of Washington
- Resource Type
- Abstract
- Publication Details
- European respiratory journal, Vol.58(Suppl. 65), p.OA103
- DOI
- 10.1183/13993003.congress-2021.oa103
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Publisher
- European Respiratory Society
- Language
- English
- Date published
- 09/05/2021
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984528093802771
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