Abstract
Enhanced vascular endothelium‐dependent dilation in older men who exercise is associated with markedly lower endothelial oxidative stress
The FASEB journal, Vol.21(6), pp.A932-A932
2007
DOI: 10.1096/fasebj.21.6.A932-b
Abstract
Compared with their sedentary peers, middle‐aged and older men who regularly perform aerobic‐endurance exercise demonstrate enhanced endothelium‐dependent dilation (EDD). This augmented EDD is believed to be mediated, at least in part, by reduced vascular oxidative stress. However, direct molecular evidence is lacking. To address this, older sedentary (OS: n=12, age 62 ± 2 yrs) and endurance exercise‐trained (OT: n=7, age 62 ± 3 yrs) healthy men were studied. Maximal oxygen consumption (VO2 max) was higher (41 ± 2 vs. 29 ± 1 ml/kg/min, p<0.01), and % body fat (%BF, 17 ± 1 vs. 28 ± 2%, p<0.01) and waist circumference (WC, 83 ± 1 vs. 96 ± 4 cm, p<0.05) were lower in OT vs. OS. EDD (brachial artery flow‐mediated dilation) was 46% higher (7.3 ± 0.8 vs. 5.0 ± 0.8%, p<0.05) in OT vs. OS. Abundance of nitrotyrosine (NT; quantitative immunofluorescence), an oxidatively modified protein, was 175% lower in endothelial cells obtained from the brachial artery of OT vs. OS (0.48 ± 0.09 vs. 1.32 ± 0.18 NT/HUVEC intensity, p<0.01). In the pooled group (n=19), VO2 max (r=−0.55, p<0.05), %BF (r=0.75, p<0.01) and WC (r=0.64, p<0.01) were related to NT. These results indicate that the enhanced EDD in exercising vs. sedentary middle‐aged and older men is associated with markedly reduced endothelial oxidative stress, perhaps related in part to their greater aerobic fitness and lower adiposity.
Supported by NIH AG13038, AG06537, AG00279, RR00051
Details
- Title: Subtitle
- Enhanced vascular endothelium‐dependent dilation in older men who exercise is associated with markedly lower endothelial oxidative stress
- Creators
- Gary L. Pierce - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Douglas R. Seals - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Iratxe Eskurza - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Annemarie E. Silver - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Phillip E. Gates - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Ashley E. Walker - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309Anthony J. Donato - Integrative PhysiologyUniversity of Colorado at BoulderUCB 354BoulderCO80309
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.21(6), pp.A932-A932
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.21.6.A932-b
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (AG13038, AG06537, AG00279, RR00051)
- Language
- English
- Date published
- 2007
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984267147602771
Metrics
6 Record Views