Abstract
Eplerenone Prevented the Large Blood Pressure Variability-Induced Aggravation of Hypertensive Cardiac Remodeling and Left Ventricular Dysfunction in Spontaneously Hypertensive Rats
Journal of cardiac failure, Vol.16(9 Suppl), pp.S160-S160
09/01/2010
DOI: 10.1016/j.cardfail.2010.07.152
Abstract
Purpose: Hypertensive patients with large blood pressure variability (BPV) show aggravated end-organ damage. There is increasing evidence that aldosterone contributes to hypertensive organ damage. However, it remained not determined whether aldosterone would participate the large BPV-induced aggravation of hypertensive cardiac remodeling. Methods and Results: We created a rat model of a combination of hypertension and large BPV by performing bilateral sinoaortic denervation (SAD) in SHRs. Rats fed on normal-salt chow. Seven weeks after operation, SAD increased BPV without changing mean BP. SAD induced LV dysfunction and aggravated myocardial fibrosis and to a lesser extent myocyte hypertrophy. Immunohistostaining revealed mineralocorticoid receptor (MR) expression in the intramyocardial coronary arterial cells and to a lesser extent the cardiac myocytes in SHR. SAD induced the translocation of the MRs to the nuclei in the coronary arterial cells and cardiac myocytes. Chronic administration of a subdepressor dose of eplerenone significantly reduced the SAD-induced myocardial fibrosis and myocyte hypertrophy. Eplerenone prevented the SAD-induced LV dysfunction. Conclusions: Large BPV induced the translocation of the MRs into the nuclei in the coronary arterial cells and cardiac myocytes. It was suggested that the endogenous aldosterone may play a role in cardiac remodeling induced by a combination of hypertension and large BPV, independently of the excessive salt intake. Eplerenone may be useful for treatment of hypertensives with large BPV.
Details
- Title: Subtitle
- Eplerenone Prevented the Large Blood Pressure Variability-Induced Aggravation of Hypertensive Cardiac Remodeling and Left Ventricular Dysfunction in Spontaneously Hypertensive Rats
- Creators
- Suguru Yasuoka - Kurume UniversityHisashi Kai - Kurume UniversityHidemi Kajimoto - Kurume UniversityTakahiro Anegawa - Kurume UniversityHiroshi Kudo - Kurume UniversityNarimasa Takayama - Kurume UniversityTutomu Imaizumi - Kurume University
- Resource Type
- Abstract
- Publication Details
- Journal of cardiac failure, Vol.16(9 Suppl), pp.S160-S160
- DOI
- 10.1016/j.cardfail.2010.07.152
- ISSN
- 1071-9164
- eISSN
- 1532-8414
- Publisher
- Elsevier Inc
- Language
- English; Japanese
- Date published
- 09/01/2010
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961111202771
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