Abstract
Estrogen, progesterone, and testosterone: gonadal hormones modulate the autonomic and myogenic responses to treadmill locomotion in rats
The FASEB journal, Vol.20(5), pp.A1401-A1401
03/2006
DOI: 10.1096/fasebj.20.5.A1401-c
Abstract
The purpose of this study was to determine the effects of various sex factors, being male vs. female and plasma estradiol (E2), progesterone (P), and testosterone (T), upon autonomic and myogenic components of cardiovascular regulation, with specific emphasis on P. Mean arterial pressure (MAP), terminal aortic blood flow (TAQ, ultrasonic flow probe), vascular conductance (VC, equals TAQ/MAP), and heart rate (HR) were determined in M, F, ovariectomized, and P‐supplemented ovariectomized Sprague‐Dawley rats (n=7 per group) during treadmill locomotion (0, 7.5, and 15 m/min). Blood samples were analyzed for E2, P, and T (immunoassay). Regression analysis revealed that sex did not influence MAP, TAQ, VC, or HR but E2 and P were each independently associated with lower MAP across the data set. E2 was also associated with greater VC, TAQ, and HR. T was associated with decreased VC and TAQ. Autonomic inhibition (hexamethonium; 10 mg/kg BW, ia) increased the strength of the estrogenic effects to lower MAP and raise VC and TAQ, and eliminated the progestagenic lowering of MAP. L‐type Ca+2 channel activity inhibition (nifedipine; 10 mg/kg BW, ip) eliminated the remaining E2‐dependent effects. Gonadal hormones may modulate the autonomic (E2, P) and myogenic (E2) components of cardiovascular regulation in rats at rest and during treadmill locomotion, with the greatest hemodynamic effects exerted by E2.
Supported by HL‐46314.
Details
- Title: Subtitle
- Estrogen, progesterone, and testosterone: gonadal hormones modulate the autonomic and myogenic responses to treadmill locomotion in rats
- Creators
- Jennifer Rogers - University of IowaDon Sheriff - The University of Iowa
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.20(5), pp.A1401-A1401
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.20.5.A1401-c
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 03/2006
- Academic Unit
- Athletic Training Program; Health and Human Physiology
- Record Identifier
- 9984267247602771
Metrics
5 Record Views