Abstract
Evaluating The Impact Of Chronic Kidney Disease And Diabetes Mellitus On Heart Failure-related Mortality: A Comprehensive Analysis Using Cdc Wonder (2000-2022)
Journal of cardiac failure, Vol.32(1), pp.221-222
01/2026
DOI: 10.1016/j.cardfail.2025.11.120
Abstract
Introduction
Chronic kidney disease (CKD) and diabetes mellitus (DM) are major contributors to heart failure (HF)-related mortality. This study analyzes national mortality trends from 2000 to 2022 using CDC WONDER, highlighting temporal changes, sex-specific differences, regional disparities, and age-related patterns.
Hypothesis
We hypothesize that mortality rates for heart failure (HF) with chronic kidney disease (CKD) and HF with diabetes mellitus (DM) have increased over time, with distinct sex, regional, and age-specific variations.
Methods
Data were extracted from the CDC WONDER database using heart failure (I50.0-I50.9), chronic kidney disease (N18.0-N18.9), and diabetes mellitus (E10-E14) ICD-10 codes (2000-2022). Temporal trends were analyzed using JoinPoint to calculate APC and AAPC, assessing disparities across sex, region, and age groups.
Results
From 2000 to 2022, mortality rates for heart failure (HF) with chronic kidney disease (CKD) and HF with diabetes mellitus (DM) exhibited significant variations. Over the full study period, HF with CKD and HF with DM demonstrated significant long-term increases (AAPC = 4.00%, p < 0.0001; AAPC = 2.67%, p < 0.0001, respectively). Sex-specific trends indicated a consistent increase in HF-related mortality with CKD for both males and females (AAPC = 4.22%, p < 0.0001). Among females with HF and DM, mortality initially increased from 2000 to 2006 (APC = 1.77%, p = 0.108), followed by a significant decline (2006-2010: APC = -10.56%, p = 0.010), and then a subsequent rise (2010-2022: APC = 6.48%, p < 0.0001). In males, HF with DM mortality remained stable until 2014 but increased sharply thereafter (APC = 9.92%, p < 0.0001). Regional analysis revealed that HF with CKD mortality increased most significantly in the South (AAPC = 4.48%) and West (AAPC = 3.91%). Conversely, for HF with DM, the Northeast and Midwest initially exhibited declining mortality but saw significant increases after 2013 (AAPC = 0.92% and 0.91%, respectively), while the South (AAPC = 2.04%) and West (AAPC = 5.93%) demonstrated the highest overall increases. Age-specific trends showed the steepest rise among individuals under 55 years with HF and CKD (AAPC = 5.80%, p < 0.0001).
Conclusion
This study confirms the rising burden of HF mortality compounded by CKD and DM. Significant temporal increases, with distinct sex, regional, and age-related patterns, highlight the need for targeted interventions, particularly among younger individuals and those in the South and West.
Details
- Title: Subtitle
- Evaluating The Impact Of Chronic Kidney Disease And Diabetes Mellitus On Heart Failure-related Mortality: A Comprehensive Analysis Using Cdc Wonder (2000-2022)
- Creators
- Muhammad Usman Usman HaiderDaniah RizwanIshtiaq AhmadZaryab BachaZahin ShahriarMian Zahid Jan KakakhelMohamed HemidaKrish PatelVyom PatelHamna JawadZaraq KhanHasan Ilyas
- Resource Type
- Abstract
- Publication Details
- Journal of cardiac failure, Vol.32(1), pp.221-222
- DOI
- 10.1016/j.cardfail.2025.11.120
- ISSN
- 1071-9164
- Publisher
- Elsevier
- Language
- English
- Date published
- 01/2026
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985129577902771
Metrics
1 Record Views