Abstract
Exercise is associated with an acute improvement in myocardial ischemic tolerance and skeletal muscle enkephalin release
The FASEB journal, Vol.21(5), pp.A570-A570
04/2007
DOI: 10.1096/fasebj.21.5.A570-c
Abstract
Exercise is associated with both increased serum opioid levels and improvements in cardiovascular health. We hypothesize that one class of opioids, the enkephalins, contributes to the acute cardioprotective effects of exercise. We further hypothesize that enkephalins are released from skeletal muscle in response to exercise, and act hormonally to evoke a cardioprotective effect. To test these hypotheses, we assessed the effect of exercise on skeletal and cardiac muscle proenkephalin (PENK) expression, as well as on myocardial ischemic tolerance. We found that exercise was profoundly cardioprotective in the rat. Additionally, exercise was associated with a change in PENK levels in skeletal and cardiac muscle, but not in intestine. Finally, hearts from exercised animals appeared to have an enhanced ischemia‐induced enkephalin release relative to control animals. These findings, coupled with our recent report that enkephalins can be absorbed from skeletal muscle and can induce a cardioprotective effect, strongly support our hypothesis that exercise‐induced enkephalin release from skeletal muscle, acting hormonally, contributes to acute cardioprotection.
Details
- Title: Subtitle
- Exercise is associated with an acute improvement in myocardial ischemic tolerance and skeletal muscle enkephalin release
- Creators
- Christopher P Hogrefe - University of IowaPaula S Ludwig - University of IowaGerene M Denning - University of IowaThomas J Barna - University of IowaLaynez W Ackermann - University of IowaLynn L Stoll - University of IowaNeal L Weintraub - University of Cincinnati Medical CenterEric W Dickson - University of Iowa
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.21(5), pp.A570-A570
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.21.5.A570-c
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2007
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984297258102771
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