Abstract
Exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study
Brain, behavior, and immunity, Vol.114(Supplement), pp.17-17
11/2023
DOI: 10.1016/j.bbi.2024.01.060
Abstract
Background: Both early (ELA) and recent life adversity (RLA) have been linked with chronic pain and persistent alterations of neuroendocrine and inflammatory responses. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic urologic disorder characterized by bladder and/or pelvic pain, and excessive urinary frequency and/or urgency. IC/BPS has been associated with high levels of ELA as well as a distinct inflammatory signature. However, associations between adversity and inflammatory mechanisms in IC/BPS that might underlie the link between adversity and symptoms have not been examined. Here we investigated ELA and RLA in women with IC/BPS as potential risk factors for inflammation and hypothalamic-pituitary-adrenal (HPA) abnormalities using data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.
Methods: Women with IC/BPS and healthy controls (n = 154 and 32, respectively) completed surveys, collected salivary cortisol at awakening and bedtime for 3 days, and gave a blood sample which was analyzed for 7 LPS-stimulated cytokines and chemokines (IL-6, TNFa, IL-1b, MIP1a, MCP1, IL-8, and IL-10). Two cytokine/chemokine composites were identified using principal components analysis.
Results: Patients with greater exposure to RLA or cumulative ELA and RLA of at least moderate severity showed elevated levels of both a global inflammatory composite of all cytokines and a regulatory cytokine composite, adjusting for age, BMI, and study site (all p values <0.05). There was a trending relationship between ELA and the global inflammatory composite. Nocturnal cortisol and cortisol slope were not associated with ELA, RLA, or inflammation. There were no relationships between inflammatory or cortisol variables and adversity in controls.
Conclusions: The present findings support the biological relevance of adverse events in IC/BPS and suggest that ELA and RLA should be assessed as risk factors for inflammation in a clinical workup for IC/BPS.
Details
- Title: Subtitle
- Exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study
- Creators
- Susan Lutgendorf - University of IowaSharaf Zia - University of IowaYi Luo - University of IowaMichael O'Donnell - University of IowaAdrie von Bokhoven - University of Colorado DenverCatherine Bradley - University of IowaRobert Gallop - West Chester UniversityJennifer Pierce - University of Michigan–Ann ArborBayley Taple - Northwestern UniversityBruce Naliboff - University of California, Los AngelesQuentin Clemens - University of Michigan–Ann ArborKarl Kreder - University of IowaAndrew Schrepf - University of Michigan–Ann Arbor
- Resource Type
- Abstract
- Publication Details
- Brain, behavior, and immunity, Vol.114(Supplement), pp.17-17
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bbi.2024.01.060
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Language
- English
- Date published
- 11/2023
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Psychological and Brain Sciences; Urology; Writers’ Workshop; Iowa Neuroscience Institute
- Record Identifier
- 9984618627102771
Metrics
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