Abstract
Expression of adipocyte/macrophage fatty acid binding protein in tumor associated macrophage promotes breast/mammary tumor progression
The Journal of immunology (1950), Vol.198(1_Supplement), pp.76-76.22
05/01/2017
DOI: 10.4049/jimmunol.198.Supp.76.22
Abstract
Abstract
Tumor associated macrophages (TAMs) play a critical role in cancer development and progression. However, due to the heterogeneity of TAMs, it remains a major challenge to identify clinically-relevant markers for pro-tumor TAMs. Here, we report that expression of adipocyte/macrophage fatty acid binding protein (A-FABP) in TAMs promotes breast cancer progression. While upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, we demonstrated that the pro-tumor effect of A-FABP was mediated by TAMs. More specifically, A-FABP was preferentially upregulated in a subset of TAMs that exhibited a CD11b+F4/80+MHCII−Ly6C− phenotype, which promoted tumor progression through IL-6/STAT3 pathway. Mechanistically, activated NFκB in A-FABP+ TAMs repressed the expression of miR-29b, resulting in enhanced tumor-promoting IL-6 signaling as compared to A-FABP −/− TAMs. Thus, A-FABP represents as a new functional marker for pro-tumor TAMs and a new target for macrophage-based tumor immunotherapy.
Details
- Title: Subtitle
- Expression of adipocyte/macrophage fatty acid binding protein in tumor associated macrophage promotes breast/mammary tumor progression
- Creators
- Jiaqing Hao - University of LouisvilleFei Yan - University of MinnesotaYuwen ZhangAshley Triplett - University of LouisvilleYing Zhang - University of MinnesotaDebra A. SchultzYanwen Sun - University of LouisvilleJun Zeng - University of LouisvilleKevin A.T. Silverstein - University of MinnesotaQi Zheng - University of LouisvilleDavid Bernlohr - University of MinnesotaMargot P. Cleary - University of MinnesotaNejat K. Egilmez - University of LouisvilleEdward SauterShujun Liu - University of MinnesotaJill Suttles - University of LouisvilleBing Li - University of Louisville
- Resource Type
- Abstract
- Publication Details
- The Journal of immunology (1950), Vol.198(1_Supplement), pp.76-76.22
- DOI
- 10.4049/jimmunol.198.Supp.76.22
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 05/01/2017
- Academic Unit
- Pathology; Surgery
- Record Identifier
- 9984695803602771
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