Expression of vascular endothelial growth factor receptor (VEGF-R) and CD31 receptor (CD31-R) in high-grade neuroendocrine carcinoma of the uterine cervix (cNEC) and its association with prognosis

James A Kuzman; Boris G Naraev; Anna M Button; Megan I Samuelson; Michael J Goodheart; Barry DeYoung; Thomas M O'Dorisio; Thorvardur Ragnar Halfdanarson

doi:10.1200/jco.2012.30.15_suppl.e15580

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Expression of vascular endothelial growth factor receptor (VEGF-R) and CD31 receptor (CD31-R) in high-grade neuroendocrine carcinoma of the uterine cervix (cNEC) and its association with prognosis

Abstract

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Expression of vascular endothelial growth factor receptor (VEGF-R) and CD31 receptor (CD31-R) in high-grade neuroendocrine carcinoma of the uterine cervix (cNEC) and its association with prognosis

James A Kuzman, Boris G Naraev, Anna M Button, Megan I Samuelson, Michael J Goodheart, Barry DeYoung, Thomas M O'Dorisio and Thorvardur Ragnar Halfdanarson

Journal of clinical oncology, Vol.30(15_suppl), pp.e15580-e15580

05/20/2012

DOI: 10.1200/jco.2012.30.15_suppl.e15580

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Abstract

e15580 Background: High-grade cNEC is uncommon cancer, and the optimal treatment is unclear. It is not known if cNEC expresses surface proteins related to angiogenesis. The aim of this study is to evaluate the expression of proteins involved in angiogenesis, as well as their possible association with clinical outcomes. Methods: Expression of VEGF-R and CD31-R was analyzed with standard immunohistochemical methods in tumor specimens from 16 patients with cNEC seen at our institution from 1977 to 2010. CD31-R expression was estimated by analyzing microvessel density using a CD31 specific antibody. Intensity and percentage of cells expressing VEGF-R was determined. Univariate survival analysis was performed using a Cox Proportional Hazard Model. Results: VEGF-R was expressed in 15 out of 16 specimens whereas CD31-R was expressed in all specimens. Increased VEGF-R expression correlated with shortened survival but the association was not statistically significant (p=0.0544, hazard ratio=1.514, CI=0.992-2.309). A one unit increase in VEGF-R expression correlated with increase in the risk of death by 51.4%. CD31-R expression showed no significant association with survival (p=0.9638,CI=0.865-1.165). Conclusions: VEGF-R and CD31-R are expressed by most cNECs. Increased VEGF-R, but not CD31-R, expression may be associated with worse survival. Further exploration of the role of angiogenesis in cervical NETs is warranted.

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Title: Subtitle: Expression of vascular endothelial growth factor receptor (VEGF-R) and CD31 receptor (CD31-R) in high-grade neuroendocrine carcinoma of the uterine cervix (cNEC) and its association with prognosis
Creators: James A Kuzman - University of Iowa Hospitals and Clinics
Boris G Naraev - University of Iowa
Anna M Button - University of Iowa
Megan I Samuelson - University of Iowa Hospitals and Clinics
Michael J Goodheart - University of Iowa Hospitals and Clinics
Barry DeYoung - University of Iowa Hospitals and Clinics
Thomas M O'Dorisio - University of Iowa Hospitals and Clinics
Thorvardur Ragnar Halfdanarson - University of Iowa
Resource Type: Abstract
Publication Details: Journal of clinical oncology, Vol.30(15_suppl), pp.e15580-e15580
DOI: 10.1200/jco.2012.30.15_suppl.e15580
ISSN: 0732-183X
eISSN: 1527-7755
Language: English
Date published: 05/20/2012
Academic Unit: Pathology; Obstetrics and Gynecology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984201522202771

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