Abstract
F194. Impairment of Sleep-Dependent Memory Consolidation and Sleep Spindles in Early-Course Schizophrenia and First-Degree Relatives
Biological psychiatry (1969), Vol.85(10), pp.S288-S289
05/15/2019
DOI: 10.1016/j.biopsych.2019.03.731
Abstract
Background
A large body of evidence has shown that sleep is critical for memory consolidation, and sleep spindles, a hallmark oscillatory feature of non-rapid eye movement sleep (NREM), facilitates this process. In chronic schizophrenia, both memory consolidation and sleep spindle function are impaired. Here we assessed whether consolidation deficits also exist in early course-patients and their first-degree relatives, and if they correlate with spindle activity.
Methods
Eleven early-course psychosis patients (n = 5 schizophrenia (ECsz), n = 6 non-schizophrenia psychosis (ECnsz), 14 first-degree relatives of psychosis patients (FDR), and 16 healthy controls (HC) participated. Sleep-dependent memory processing on the finger tapping motor sequence task (MST) and a word pairs task (WPT) was investigated. We expected poorer consolidation on both tasks and a correlated reduction in spindle density in the ECsz and FDR groups.
Results
On the MST, HC, FDR, and ECnsz showed 9-16% improvement, while ECsz showed -1% (p = .034, ECsz vs all other groups). For the WPT, HC and ECnsz showed similarly minimal overnight forgetting (2 and 3%), while FDR and ECsz showed significantly more forgetting (11 and 17%; p = .041). Spindle density showed a trend for being lower in EC groups compared to HC and FDR (p = .090), and correlated with MST improvement (r = 0.40, p .048).
Conclusions
Results showed that deficits in MST and WPT memory consolidation and in sleep spindle density, which are seen in chronic schizophrenia, also exist in early course patients. Furthermore, declarative memory consolidation is also impaired in first-degree relatives of psychosis patients.
Details
- Title: Subtitle
- F194. Impairment of Sleep-Dependent Memory Consolidation and Sleep Spindles in Early-Course Schizophrenia and First-Degree Relatives
- Creators
- Dan Denis - Beth Israel Deaconess Medical Center, Harvard Medical SchoolOlivia Larson - Masschusetts General Hospital & Harvard Medical SchoolErina Sato - Beth Israel Deaconess Medical Center, Harvard Medical SchoolErin Kohnke - Masschusetts General Hospital & Harvard Medical SchoolElaine Parr - Beth Israel Deaconess Medical Center, Harvard Medical SchoolBengi Baran - Masschusetts General Hospital & Harvard Medical SchoolKatherine Stewart - Beth Israel Deaconess Medical Center, Harvard Medical SchoolCasey Cragin - Beth Israel Deaconess Medical CenterCorin Pilo - Beth Israel Deaconess Medical CenterCourtney Spitzer - Beth Israel Deaconess Medical CenterNimita E Iyer - Beth Israel Deaconess Medical CenterJulie King - Beth Israel Deaconess Medical CenterMatcheri Keshavan - Beth Israel Deaconess Medical Center, Harvard Medical SchoolDara S Manoach - Masschusetts General Hospital & Harvard Medical SchoolRobert Stickgold - Beth Israel Deaconess Medical Center, Harvard Medical School
- Resource Type
- Abstract
- Publication Details
- Biological psychiatry (1969), Vol.85(10), pp.S288-S289
- DOI
- 10.1016/j.biopsych.2019.03.731
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 05/15/2019
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Center for Social Science Innovation
- Record Identifier
- 9984071758702771
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