Abstract
FRI0038 Correlation between clinical and ultrasonographic remission? the effect of non-inflammatory patient-based factors on different remission definitions
Annals of the rheumatic diseases, Vol.77(Suppl 2), p.566
06/2018
DOI: 10.1136/annrheumdis-2018-eular.5811
Abstract
ObjectivesIn this study, we aimed to investigate the concordance of ultrasonographic remission with other remission criteria and to show the influence of non-inflammatory patient-induced factors such as depression, anxiety, fibromyalgia and fatigue on both clinical and ultrasonographic remission.MethodsFifty consecutive patients with clinical remission (DAS-28-ESR<2.6) who were diagnosed according to the 2010 ACR/EULAR criteria were recruited to this study.Patients were also assessed whether they met the Boolean and SDAI remission criteria. 28 joint grey scale (GS) and power Doppler (PD) ultrasonography were performed. Patients‘ depression and anxiety were assessed by The Hospital Anxiety and Depression Scale (HADS), and their fatigue was assessed by multidimensional Assessment of Fatigue (MAF) scores and patients’ fibromyalgia was assessed by widespread pain index (WPI) and symptom severity score (SS).ResultsPatients were divided into 4 groups according to different remission definitions by ultrasonography. (Group1: PD=0 and GS=0, Group2: PD=0 and GS ≥0, Group3: PD=1 or 0 and GS=1 or 0, Group4: PD=1 or 0 and GS ≥0).Although it is not statistically significant, the highest agreement with all the clinical remission criteria was found in the USG remission group 4 (table 1).Patients with ultrasonographic remissions at their first visit in 2011 were reevaluated with clinical remission criteria at the end of 5 years. The highest remission rates were found in patients with USG remission group 3 (DAS28 58%, Boolean 29%, SDAI 47%). There was no significant difference between fatigue, fibromyalgia, depression and anxiety measures between remission and non-remission in all USG remission groups. In contrast, depression (p<0.05) and anxiety (p<0.03) were significantly higher in patients without SDAI remission. Depression (p<0.008) and anxiety (p<0.014) were also significantly higher in patients without Boolean remission.Abstract FRI0038 – Table 1The concordance between Ultrasound remission and other remission criteriaDas28 (n=50)SDAI (n=23)Boolean (n=22) Group 1: PD=0 GS=0n (%)13 (% 26)8(%34,7)5 (%22,7)Group 2: PD=0 GS≥0n (%)22 (% 44)10 (%43,4)8(%36,3)Group 3: PD=1 or 0 and GS=1 or 0n (%)17 (%34)8 (%34,7)7 (%31,8)Group 4: PD=1 or 0 and GS≥0n (%)28 (%56)13(%56,5)11 (%50)ConclusionsClinical and ultrasonographic remission was found to be compatible in half of the patients.The compliance of the USG remission in Group 4 with the clinical remission definitions was good, and clinical remission continuity was higher in the group meeting the definition of group 3. In contrast the ultrasound remission, the high levels of depression and anxiety in patients without SDAI and Boolean remission suggest that non-inflammatory patient-derived measures have less influence on the ultrasound remission.Disclosure of InterestNone declared
Details
- Title: Subtitle
- FRI0038 Correlation between clinical and ultrasonographic remission? the effect of non-inflammatory patient-based factors on different remission definitions
- Creators
- Ü. Gazel - Marmara UniversityS. Yılmaz-Öner - Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma HastanesiG. Özen - Rheumatology, Bakırköy Sadi Konuk Research and Training Hospital, Istanbul, TurkeyY. Yalçınkaya - Marmara UniversityZ. Ertürk - Rheumatology, Bakırköy Sadi Konuk Research and Training Hospital, Istanbul, TurkeyM.P. Atagündüz - Rheumatology, Bakırköy Sadi Konuk Research and Training Hospital, Istanbul, TurkeyH. Direskeneli - Marmara UniversityN. İnanç - Marmara University
- Resource Type
- Abstract
- Publication Details
- Annals of the rheumatic diseases, Vol.77(Suppl 2), p.566
- Publisher
- BMJ PUBLISHING GROUP; LONDON
- DOI
- 10.1136/annrheumdis-2018-eular.5811
- ISSN
- 0003-4967
- eISSN
- 1468-2060
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702768902771
Metrics
1 Record Views