Abstract
GAINING INSIGHT TO THE UNDERLYING NEURAL MECHANISMS BY WHICH EXERCISE IMPROVES MOBILITY
Innovation in aging, Vol.1(Suppl 1), pp.585-585
07/01/2017
DOI: 10.1093/geroni/igx004.2053
PMCID: PMC6246208
Abstract
Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, our main objective was to investigate whether six months of progressive aerobic exercise training alters frontoparietal network (FPN) connectivity during a motor task among older adults at risk for mobility disability – individuals with mild subcortical ischemic vascular cognitive impairment (SIVCI)—and whether exercise-induced changes in FPN connectivity correlate with concurrent changes in mobility. We focused on the FPN as it is involved in top-down attentional control as well as motor planning and motor execution. Participants were randomized either to usual-care (CON) or thrice-weekly aerobic training (AT). Functional magnetic resonance imaging was acquired at baseline and trial completion. At trial completion, compared with AT, CON showed significantly increased FPN connectivity strength during right finger tapping (p<0.05). Across the participants, reduced FPN connectivity was associated with greater cardiovascular capacity (p=0.05). In the AT group, reduced FPN connectivity was significantly associated with improved mobility performance, as measured by the Timed-Up-and-Go test (r=0.67, p=0.02). These results suggest progressive aerobic training may improve mobility in older adults with SIVCI via maintaining intra-network connectivity of the FPN.
Details
- Title: Subtitle
- GAINING INSIGHT TO THE UNDERLYING NEURAL MECHANISMS BY WHICH EXERCISE IMPROVES MOBILITY
- Creators
- C Hsu - Rehabilitation Science, University of British ColumbiaJ Best - Rehabilitation Science, University of British ColumbiaS Wang - Rehabilitation Science, University of British ColumbiaM Voss - University of IowaR.G Hsiung - Rehabilitation Science, University of British ColumbiaM Munkacsy - Aging, Mobility, and Cognitive Neuroscience LabT Handy - Rehabilitation Science, University of British ColumbiaT Liu-Ambrose - Rehabilitation Science, University of British Columbia
- Resource Type
- Abstract
- Publication Details
- Innovation in aging, Vol.1(Suppl 1), pp.585-585
- Publisher
- Oxford University Press; US
- DOI
- 10.1093/geroni/igx004.2053
- PMCID
- PMC6246208
- ISSN
- 2399-5300
- eISSN
- 2399-5300
- Language
- English
- Date published
- 07/01/2017
- Academic Unit
- Iowa Neuroscience Institute; Psychological and Brain Sciences
- Record Identifier
- 9984071742502771
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