Abstract
GENDER DIFFERENCES IN MYOCARDIAL BLOOD FLOW IN CARDIAC PET/CT WITH REGADENOSON
Journal of the American College of Cardiology, Vol.65(10 Supplement), pp.A1270-A1270
03/17/2015
DOI: 10.1016/S0735-1097(15)61270-0
Abstract
Background:
Little is known regarding myocardial blood flow (MBF) values in subjects undergoing PET/CT stress testing using regadenoson. Specifically, it is unknown what differences in MBF, if any, exist between genders. We analyzed patients without cardiac risk factors with normal perfusion images to evaluate differences in rest and stress MBF as well as coronary flow reserve (CFR) (stress flow/rest flow) values based upon gender.
Methods:
Patients (n=241) who underwent cardiac PET/CT stress testing between March 2013 and July 2014 were selected from the Intermountain Healthcare's PET/CT database. Subjects with abnormal perfusion scans, ejection fractions <40% via PET, and cardiac risk factors were excluded.
Results:
Table: Global rest and stress myocardial blood flow in mL/min/g and coronary flow reserve on Cardiac PET/CT in normal subjects by gender.
Conclusion:
Global MBF at rest is higher in normal female subjects resulting in a lower CFR in women, as stress flows were similar regardless of gender. This pattern may have key implications in the interpretation of normal vs. abnormal CFR in women. Furthermore, the overall stress and reserve MBF values with regadenoson are notably lower than those previously described using adenosine/dipyridamole, potentially reflecting a lesser degree of vasodilation and more limited augmentation of flow with this widely used pharmacological stress agent.
Details
- Title: Subtitle
- GENDER DIFFERENCES IN MYOCARDIAL BLOOD FLOW IN CARDIAC PET/CT WITH REGADENOSON
- Creators
- Jason Allen - University of UtahSteve Mason - University of UtahJon-David EthingtonJeffrey Anderson - University of UtahRaymond McCubrey - University of UtahViet Le - University of UtahRitesh Dhar - University of UtahKent Meredith - University of UtahHannah Raasch - University of Utah
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.65(10 Supplement), pp.A1270-A1270
- DOI
- 10.1016/S0735-1097(15)61270-0
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Publisher
- Elsevier Limited
- Language
- English
- Date published
- 03/17/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984697716302771
Metrics
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