Abstract
Gastric Bypass Sensitizes Sympathetic and Thermogenic Activity of BAT to Cold Exposure
Obesity (Silver Spring, Md.), Vol.29, pp.107-107
12/01/2021
Abstract
Background: We recently demonstrated that the increase in resting metabolic rate post Roux-en-Y Gastric Bypass (RYG) is due to a sympathetically mediated increase in thermogenic activity in visceral white adipose tissue (WAT), but not brown adipose tissue (BAT), at normal room temperature. Thus, BAT activity might not be contributing to energy balance post-RYGB under normal daily condition but might be engaged when temperature change. Methods: To test this, we examined the effect of RYGB on BAT sympathetic tone and thermogenic capacity upon cold exposure in mice. To exclude weight as a variable, performed our studies in weightmatched animals. Results: We report that cooling induces a significant increase in BAT sympathetic nerve activity (SNA) in RYGB-operated mice (Figure 1A, B) one-week post-surgery when sham and bypass-operated animals are weight matched (Figure 1C). Furthermore, the cooling did not cause any significant change in blood pressure or heart rate between the two groups suggesting this sympathetic reflex is not systemic or stress-induced (Figure 1D). Consistent with the SNA data, cold exposure to a core temperature of 27-28 °C induces thermogenic surge in BAT TH and UCP1 expression post-RYGB (Figure 2A). Likewise, 2-deoxy-glucose uptake was increased by BAT in RYGB-operated mice compared to their sham counterparts when experiment was performed under cold but not warm temperature conditions (Figure 2B). Conclusions: In summary, our data show that BAT activity is plastic post-RYGB and might be accountable for the day-to-day variations in thermogenic activity and possibly the other metabolic benefits of bariatric surgery.
Details
- Title: Subtitle
- Gastric Bypass Sensitizes Sympathetic and Thermogenic Activity of BAT to Cold Exposure
- Creators
- Mohamad MokademYi ChuLiping TianHussein HerzBenjamin LindenDonald MorganMegan NaberMatthew PothoffKamal Rahmouni
- Resource Type
- Abstract
- Publication Details
- Obesity (Silver Spring, Md.), Vol.29, pp.107-107
- Publisher
- Blackwell Publishing Ltd
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984363172402771
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