Abstract
Genetic Evaluation of Living Kidney Donor Candidates: Results from the LDGen Registry: SA-PO968
Journal of the American Society of Nephrology, Vol.35(10S)
10/2024
DOI: 10.1681/ASN.2024wjmzmfm2
Abstract
Background:
We describe our preliminary experience with the launch of a novel international Registry – “LDGen” – as a repository to study current and evolving practices in genetic testing as part of living donor (LD) candidate evaluation.
Methods:
A cross-sectional, electronic REDCap registry was developed to collect information on LD candidates and their genetic test results. LD candidates who either 1) underwent genetic testing, and/or 2) had a family history of genetic kidney disease, or 3) are looking to donate to a related recipient with kidney disease of unknown etiology were registered. Data reported here were collected between June, 2023 and May, 2024.
Results:
Data on 1004 LD evaluations were obtained representing 12 U.S. and 9 international centers. 39% (n=305) of intended recipients had possible genetic kidney disease. Genetic testing was performed in 17% (n=168) of LD evaluations. Testing in recipient candidate was performed before the LD candidate in 73% (n=122) of cases while it was performed only in the donor candidate in 27% (n=46) of evaluations (Fig. 1A). 125 LD candidates underwent genetic testing and 81% of these donors received formal pre-test genetic counseling. Single gene/limited gene panel (42%) and broad kidney disease gene panel (29%) were the most common methods. 33% (n=41) of the LD candidates who underwent genetic testing during evaluation were not accepted, of which 51% (n=21) of declinations were due to the genetic testing result [Pathogenic/Likely pathogenic variant (n=9), renal risk variants (n=2), VUS (n=10)] (Fig.1B).
Conclusion:
Our initial experience supports the feasibility of international collaboration in creating a registry of genetic kidney disease testing practices among LD candidates. With more data, the findings of the LDGen registry will provide value information on global LD evaluation practice patterns.
Details
- Title: Subtitle
- Genetic Evaluation of Living Kidney Donor Candidates: Results from the LDGen Registry: SA-PO968
- Creators
- Yasar Caliskan - Saint Louis UniversityOzgur Akin Oto - Istanbul UniversityTarek Alhamad - Washington University in St. LouisHalil Yazici - Istanbul Yeni Yüzyıl UniversityAbdulmecit Yildiz - Bursa Uludağ Üni̇versi̇tesi̇Arzu Velioglu - Marmara UniversityNeetika Garg - University of Wisconsin–MadisonKarim Soliman - Medical University of South CarolinaArksarapuk Jittirat - Case Western Reserve UniversityOndrej Viklicky - Institute of Clinical and Experimental MedicineZeynep Ural - Gazi UniversityChristina Irene Mejia - Johns Hopkins UniversityReem Daloul - Allegheny Health NetworkDanilo Radunovic - Klinički Centar Crne GoreBrian Lee - Seton Medical CenterChristie P. Thomas - University of IowaHernando Trujillo Cuellar - Hospital Universitario 12 De OctubreRoslyn B. Mannon - University of Nebraska SystemKrista L. Lentine - Saint Louis University
- Resource Type
- Abstract
- Publication Details
- Journal of the American Society of Nephrology, Vol.35(10S)
- Publisher
- AMER SOC NEPHROLOGY; WASHINGTON
- DOI
- 10.1681/ASN.2024wjmzmfm2
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Language
- English
- Date published
- 10/2024
- Academic Unit
- Obstetrics and Gynecology; Internal Medicine; Nephrology; Stead Family Department of Pediatrics
- Record Identifier
- 9984740858402771
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