Abstract
Heart Failure And Pancreatic Cancer Understanding The Cardio Oncology Intersection A 23 Year U.s. Mortality Analysis Using Cdc Wonder
Journal of cardiac failure, Vol.32(1), p.358
01/2026
DOI: 10.1016/j.cardfail.2025.11.458
Abstract
Introduction
Heart failure (HF) and pancreatic cancer (PC) have high mortality rates. While links between cancer and heart disease are emerging, trends in HF and PC deaths remain unclear. This study analyzes U.S. mortality trends of HF and PC over 23 years
Methods
We used the CDC WONDER database (1999-2023) to assess HF and PC mortality. Age-adjusted mortality rates (AAMR) were calculated, with p-values determining statistical significance.
Results
Mortality trends remained stable from 1999 to 2012 before surging, peaking at 473,263 deaths in 2022, then slightly declining to 466,842 in 2023. AAMR dropped from 226.86 per 100,000 in 1999 to 180.66 in 2012 before rising to 229.81 in 2021, likely due to COVID-19, then falling to 216.50 in 2023.Sex: Women’s AAMR fell from 202.62 (1999) to 158.00 (2012), peaked at 195.94 (2021), then declined to 185.12 (2023). Men’s AAMR dropped from 262.38 (1999) to 211.93 (2012), peaked at 273.49 (2021), then fell to 256.55 (2023). Race: Black individuals had the highest AAMR, peaking at 257.67 (2021), then declining to 239.75 (2023). Whites peaked at 234.43 (2021), then fell to 222.08 (2023). Other racial groups followed similar trends. Place of Death: Inpatient deaths declined (133,371 in 1999 to 98,678 in 2012) but rose to 143,675 (2022). Home deaths increased (63,785 in 1999 to 171,507 in 2021). Hospice deaths surged from 667 (2003) to 36,544 (2023).Geography: The Midwest had the highest AAMR (255.67 in 2021). The South followed (238.43 in 2021), while the Northeast and West had lower but persistent post-pandemic spikes.Urbanization: Large Central Metros saw deaths rise from 79,697 (1999) to 110,252 (2020). NonCore areas had the highest AAMR (271.06 in 2020), reflecting severe pandemic impact.
Conclusion
Our 23-year analysis highlights a resurgence in HF and PC mortality post-2012, with disparities across sex, race, region, and urbanization. The COVID-19 pandemic exacerbated trends, emphasizing the need for targeted cardio-oncology interventions and improved healthcare access to reduce risks.
Details
- Title: Subtitle
- Heart Failure And Pancreatic Cancer Understanding The Cardio Oncology Intersection A 23 Year U.s. Mortality Analysis Using Cdc Wonder
- Creators
- Ishtiaq Ahmad - Geisinger Wyoming Valley Medical CenterMuhammad Usman Haider - Geisinger Wyoming Valley Medical CenterHasan Ilyas - Delray Medical CenterFedor Cabrera - Geisinger Wyoming Valley Medical CenterMian Zahid Jan Kakakhel - Khyber Medical CollegeZaraq Khan - Vincennes UniversitySaniya Ishtiaq - Rawalpindi Medical UniversityMaryam Tariq - Punjab Medical CollegeZaryab Bacha - Khyber Medical UniversityMUHAMMAD Uzair - Liaquat University of Medical & Health SciencesAbdullah Afridi - Khyber Medical CollegeVyom Patel - Vincennes University
- Resource Type
- Abstract
- Publication Details
- Journal of cardiac failure, Vol.32(1), p.358
- DOI
- 10.1016/j.cardfail.2025.11.458
- ISSN
- 1071-9164
- Publisher
- Elsevier
- Language
- English
- Date published
- 01/2026
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985129653502771
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