Abstract
High-Fat Diet-Induced Obesity Accelerates Platelet-Driven Thrombosis
Free radical biology & medicine, Vol.240, p.S1
11/2025
DOI: 10.1016/j.freeradbiomed.2025.10.013
Abstract
Obesity is a major global epidemic and a risk factor for thrombotic events such as myocardial infarction and ischemic stroke. However, the mechanisms remain poorly defined. We addressed this gap in knowledge using C57BL/6J mice fed a high-fat diet (HFD) or standard chow for 12 weeks starting at 6 weeks of age. HFD-fed mice developed impaired glucose tolerance and exhibited increased platelet activation, evidenced by greater integrin activation and granule release demonstrated via flow cytometry. Thrombotic susceptibility was tested using photochemical carotid artery injury and collagen-induced pulmonary thrombosis models. Obese mice demonstrated faster time to carotid arterial occlusion, and reduced survival. In adoptive transfer experiments we showed that compared to platelets from mice fed chow diet, mice fed HFD caused accelerated thrombus formation in host mice. We conclude that obesity induces platelet activation and increases susceptibility to thrombosis. On going study is investigating contributions of lipid uptake and fatty acid oxidation in driving platelet activation and thrombosis in obesity.
Details
- Title: Subtitle
- High-Fat Diet-Induced Obesity Accelerates Platelet-Driven Thrombosis
- Creators
- Azaj AhmedMelissa JensenSanjana Dayal
- Resource Type
- Abstract
- Publication Details
- Free radical biology & medicine, Vol.240, p.S1
- DOI
- 10.1016/j.freeradbiomed.2025.10.013
- ISSN
- 0891-5849
- eISSN
- 1873-4596
- Publisher
- ELSEVIER SCIENCE INC
- Language
- English
- Date published
- 11/2025
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9985024252702771
Metrics
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