Abstract
Higher central and brachial artery systolic and pulse pressure in black overweight/obese adolescents: relation with aortic stiffness and pressure wave reflection
The FASEB journal, Vol.25, pp.640.33-640.33
04/2011
DOI: 10.1096/fasebj.25.1_supplement.640.33
Abstract
We determined if elevated central and brachial systolic blood pressure (BP) and pulse pressure (PP) in overweight/obese (OW/OB) adolescents is related to increased aortic stiffness (carotid‐femoral pulse wave velocity, CF‐PWV) or pressure wave reflection (augmentation index, AI). OW/OB (n=85; age 17.0 ± 0.2 yrs; BMI≥85%ile) black adolescents demonstrated 5–6% higher brachial and central systolic BP and 11–16% higher brachial and central PP (all P<0.01) compared with healthy‐weight (HW, n=141; age 16.8 ± 0.1 yrs; BMI <85%ile). OW/OB had 7% higher CF‐PWV (5.7 ± 0.1 vs. 5.3 ± 0.1 m/sec, P<0.01) compared with HW, but no difference in AI between groups (P>0.05). In the entire cohort (n=226) after adjusting for age, sex, heart rate, height, and mean BP, CF‐PWV was positively related to BMI%ile (r=0.22, P<0.01), waist and hip girth (r=0.17, 0.20, P<0.05), but not to central or brachial systolic BP, PP or AI. Paradoxically, AI was inversely related to brachial and central systolic BP (r=−0.35 and −0.52, both P<0.01) and PP (r=−0.29 and −0.44, both P<0.01). These data suggest that higher central and brachial systolic BP and PP in OW/OB adolescents is likely mediated by an augmented forward pressure wave amplitude from enhanced proximal aortic characteristic impedance rather than greater aortic stiffness or reflected pressure wave. Supported by NIH R01 HL077230‐02 and MCG Child Health Discovery Institute.
Details
- Title: Subtitle
- Higher central and brachial artery systolic and pulse pressure in black overweight/obese adolescents: relation with aortic stiffness and pressure wave reflection
- Creators
- Gary L Pierce - Medical College of GeorgiaHaidong Zhu - Medical College of GeorgiaInger Stallmann‐Jorgensen - Medical College of GeorgiaYing Huang - Medical College of GeorgiaDehuang Guo - Medical College of GeorgiaItoro Edet - Medical College of GeorgiaKatie Darracott - Medical College of GeorgiaYanbin Dong - Medical College of Georgia
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.25, pp.640.33-640.33
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.640.33
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (R01 HL077230‐02) MCG Child Health Discovery Institute
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984267146802771
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