IMPACT OF CHRONIC TOTAL OCCLUSION ON VENTRICULAR ARRHYTHMIA AND MORTALITY IN ISCHEMIC CARDIOMYOPATHY PATIENT WITH IMPLANTABLE CARDIAC DEFIBRILLATOR: A SYSTEMATIC REVIEW AND META-ANALYSIS

Wasawat Vutthikraivit; Saranapoom Klomjit; Pattara Rattanawong; Pakpoom Tantrachoti; Pavida Pachariyanon; Awapa Prombandankul; Possawat Vutthikraivit; Mohammad Ansari

doi:10.1016/S0735-1097(18)31602-4

Back

IMPACT OF CHRONIC TOTAL OCCLUSION ON VENTRICULAR ARRHYTHMIA AND MORTALITY IN ISCHEMIC CARDIOMYOPATHY PATIENT WITH IMPLANTABLE CARDIAC DEFIBRILLATOR: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

Peer reviewed

IMPACT OF CHRONIC TOTAL OCCLUSION ON VENTRICULAR ARRHYTHMIA AND MORTALITY IN ISCHEMIC CARDIOMYOPATHY PATIENT WITH IMPLANTABLE CARDIAC DEFIBRILLATOR: A SYSTEMATIC REVIEW AND META-ANALYSIS

Wasawat Vutthikraivit, Saranapoom Klomjit, Pattara Rattanawong, Pakpoom Tantrachoti, Pavida Pachariyanon, Awapa Prombandankul, Possawat Vutthikraivit and Mohammad Ansari

Journal of the American College of Cardiology, Vol.71(11 Supplement), pp.A1061-A1061

03/10/2018

DOI: 10.1016/S0735-1097(18)31602-4

View Online

Abstract

Background Recent studies suggested that chronic total occlusion of the coronary artery increased risk of ventricular arrhythmia (VA) and all-cause mortality in ischemic cardiomyopathy (ICM) patient who underwent implantable cardiac defibrillator (ICD) implantation. We aim to determine adverse events in this population. Methods We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. The studies that compared adverse events (appropriate shock and all-cause mortality) between patients with and without CTO of the coronary artery who had ICD were included for meta-analysis. Results Five studies from 2015 to 2017 were included in this meta-analysis involving 1,095 subjects (505 CTO and 590 non-CTO). The presence of CTO was significantly associated with increased risk of appropriated shock (pooled risk ratio =1.60, 95% confidence interval: 1.29-1.99, p<0.001, I2=73.2%) and all-cause mortality (pooled risk ratio=1.65, 95 % confidence interval: 1.22-2.24, p=0.008, I2=35.1%) in ICD implanted ICM patients (figure 1.1 and 1.2). Conclusion Presence of CTO of the coronary artery increased risk of appropriate shock following VA and all-cause mortality in ICD implanted ICM patients up to 60 and 71 percent, respectively. Our study suggested that CTO is an independent predictor of unfavorable outcome and must be addressed in ICM patients with ICD.

Details

Title: Subtitle: IMPACT OF CHRONIC TOTAL OCCLUSION ON VENTRICULAR ARRHYTHMIA AND MORTALITY IN ISCHEMIC CARDIOMYOPATHY PATIENT WITH IMPLANTABLE CARDIAC DEFIBRILLATOR: A SYSTEMATIC REVIEW AND META-ANALYSIS
Creators: Wasawat Vutthikraivit - Texas Tech University Health Sciences Center
Saranapoom Klomjit - Texas Tech University Health Sciences Center
Pattara Rattanawong - Texas Tech University Health Sciences Center
Pakpoom Tantrachoti - Texas Tech University Health Sciences Center
Pavida Pachariyanon - Texas Tech University Health Sciences Center
Awapa Prombandankul - Texas Tech University
Possawat Vutthikraivit - Texas Tech University
Mohammad Ansari - Texas Tech University
Resource Type: Abstract
Publication Details: Journal of the American College of Cardiology, Vol.71(11 Supplement), pp.A1061-A1061
Publisher: ELSEVIER SCIENCE INC
DOI: 10.1016/S0735-1097(18)31602-4
ISSN: 0735-1097
eISSN: 1558-3597
Language: English
Date published: 03/10/2018
Academic Unit: Internal Medicine
Record Identifier: 9984695806402771

Metrics

1 Record Views