Abstract
INCIDENCE OF ATRIAL FIBRILLATION DURING PREGNANCY AND ITS IMPACTS ON MATERNAL AND FETAL OUTCOMES: A META-ANALYSIS
Journal of the American College of Cardiology, Vol.73(9 Supplement 1), pp.356-356
03/12/2019
DOI: 10.1016/S0735-1097(19)30964-7
Abstract
Background
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide, and is associated with increased morbidity and mortality. However, the incidence and maternal/fetal outcomes of AF in pregnancy remain unclear. This study's aims were 1) to investigate the pooled incidence of AF in pregnant women and 2) to assess maternal/fetal outcomes of AF in pregnancy.
Methods
A literature search for studies that reported incidence of AF in pregnancy, was conducted using MEDLINE, EMBASE and Cochrane Database from inception through May 2018. Pooled incidence with 95%CI were calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO; no. CRD42018095955.
Results
7 cohort studies including 301,638 pregnancies were identified. The pooled estimated incidence of AF in pregnancy among women with no known heart disease, and those with structural heart disease was 0.3% (95%CI: 0.01%-40.6%) and 2.2% (95%CI: 0.96%-5.01%), respectively. Among women with known AF, the pooled estimated incidence of recurrent AF in pregnancy was 39.2% (95%CI: 16.9%-67.2%). The pooled estimated incidence of pre-eclampsia and congestive heart failure among pregnant patients with AF was 4.1% (95%CI: 2.1%-7.8%) and 9.6% (95%CI: 5.7%-15.9%), respectively. The pooled estimated incidence of fetal events including premature birth, small for gestational age, respiratory distress syndrome, intraventricular hemorrhage, death was 26.6% (95%CI: 20.4%-34.0%). Egger's regression asymmetry test showed no publication bias in our meta-analysis.
Conclusion
While AF is uncommon during pregnancy with no known heart disease, the overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
Details
- Title: Subtitle
- INCIDENCE OF ATRIAL FIBRILLATION DURING PREGNANCY AND ITS IMPACTS ON MATERNAL AND FETAL OUTCOMES: A META-ANALYSIS
- Creators
- Pavida Pachariyanon - Texas Tech University Health Sciences CenterWisit Cheungpasitporn - Texas Tech University Health Sciences CenterTarun Bathini - Texas Tech University Health Sciences CenterOisin A. O'CorragainCharat Thongprayoon - Texas Tech University Health Sciences CenterRonpichai Chokesuwattanaskul - Texas Tech University Health Sciences Center
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.73(9 Supplement 1), pp.356-356
- Publisher
- ELSEVIER SCIENCE INC
- DOI
- 10.1016/S0735-1097(19)30964-7
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Language
- English
- Date published
- 03/12/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695823802771
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