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IP16-01 COMPARING URINARY URGENCY PATIENTS WITH AND WITHOUT PAIN - A LURN II STUDY
Abstract   Peer reviewed

IP16-01 COMPARING URINARY URGENCY PATIENTS WITH AND WITHOUT PAIN - A LURN II STUDY

H. Henry Lai, Jon Wiseman, Brian Bieber, Cindy Amundsen, Eric Jelovsek, Anne Cameron, J. Quentin Clemens, Catherine Bradley, Karl Kreder, Claire Yang, …
The Journal of urology, Vol.215(5S), p.e332
05/2026
DOI: 10.1097/01.JU.0001191360.00345.d8.01

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Abstract

INTRODUCTION AND OBJECTIVES: Urinary urgency (the cardinal symptom of OAB) and pain are both subjective noxious sensations. Some OAB patients experience pain in addition to urinary urgency. 54% of adult women with OAB symptoms stated that their urge to urinate was associated with pain, pressure, or discomfort (Reynolds et al 2017). The objective of this study was to phenotype urinary urgency patients with pain, and to compare to urgency patients without pain. METHODS: Adults seeking treatment for bothersome urinary urgency, without or with urgency urinary incontinence, were enrolled in the LURN II Study. A sex-matched control group without urinary symptoms was also enrolled. Urgency was assessed using the LURN SI-29s? subscale. Urologic pain was assessed using the GUPI (genitourinary pain index) pain subscale and LURN SI-29 pain subscale. Widespread pain was defined as pain involving 3 or more body regions on a pain map. Urologic and widespread pain were compared urgency patients and controls. Patients with a diagnosis of IC/BPS were excluded. RESULTS: Urgency patients (n=742) were significantly more likely to report any urologic pain on GUPI (49% vs. 11%, p<0.01) and LURN SI-29 (56% vs. 23%, p<0.01) compared to controls without urgency (n=139). GUPI pain subscale scores were higher among urgency patients compared to controls (mean 4.3 vs. 0.7, p<0.01). LURN SI-29 pain subscale scores were also higher among urgency patients compared to controls (13.3. vs. 2.3, p<0.01). Urgency patients were also more likely to report widespread pain on the pain map than controls (32% vs. 14%, p<0.01). There were significant positive correlations between worsening LURN SI-29 pain scores and OAB-q scores, LURN SI-29 urgency subscale scores, and LURN SI-29 incontinence subscale scores (see Figure). * [means p<0.05; number in figure=correlation coefficient]. CONCLUSIONS: In care-seeking patients with urinary urgency, over half reported mild urologic pain and one-third reported widespread pain. There were positive correlations between their OAB and pain symptoms. These data support the concept that OAB patients may have heightened sensitivity to noxious stimulation and/or central sensitization. Studies are needed to examine if urgency patients with pain might represent a distinct phenotype.

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