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IP16-02 COMPARING SYMPTOM PRESENTATION, TREATMENT PATTERNS, AND SYMPTOM TRAJECTORIES BETWEEN MEN AND WOMEN WITH URINARY URGENCY - A LURN II STUDY
Abstract   Peer reviewed

IP16-02 COMPARING SYMPTOM PRESENTATION, TREATMENT PATTERNS, AND SYMPTOM TRAJECTORIES BETWEEN MEN AND WOMEN WITH URINARY URGENCY - A LURN II STUDY

H. Henry Lai, Alan Fossa, Brian Bieber, Cindy Amundsen, Eric Jelovsek, Anne Cameron, J. Quentin Clemens, Catherine Bradley, Karl Kreder, Claire Yang, …
The Journal of urology, Vol.215(5S), p.e332
05/2026
DOI: 10.1097/01.JU.0001191360.00345.d8.02

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Abstract

INTRODUCTION AND OBJECTIVES: Overactive bladder (OAB) in men is poorly understood and under-studied. The co-occurrence of storage and voiding symptoms makes it challenging to recognize and manage. The objectives of this study were to compare the symptom presentation, treatment patterns, and symptom trajectories between men and women with urinary urgency, the cardinal symptom of OAB. METHODS: Adult men and women seeking treatment for bothersome urinary urgency, without or with urgency urinary incontinence, were enrolled in the LURN II Study. Patients with a clinical impression of bladder outlet obstruction or pain as a primary diagnosis were excluded. LUTS were assessed using the OAB-q and LURN SI-29 questionnaires at baseline, 3, 6, 9, and 12-month. Treatment data were queried during study visits. RESULTS: 272 men and 339 women with urinary urgency were enrolled. Men were older and reported less severe OAB-q symptoms and better HRQL at baseline compared to women. Men also had lower LURN SI-29 total scores, urgency scores, and incontinence scores compared to women. Conversely, men reported higher nocturia and voiding scores compared to women. In terms of treatment patterns, more men used BPH medications (61% alpha blockers, 19% 5-alpha reductase) than OAB medications (40% anticholinergics, 22% beta-agonists). It was uncommon for men to do pelvic floor muscle exercises (3.1%) or pelvic floor physical therapy (4.2%) to manage their urgency (see Table). Although men had less severe OAB symptoms at baseline, there was greater improvement in OAB symptoms and HRQL over time among women, such that there were no differences between them at follow-up (see Figure). CONCLUSIONS: At baseline, women reported more severe urgency, incontinence, and overall OAB burden, whereas men had higher nocturia and voiding scores. Despite these sex-specific differences, women experienced greater improvement in urgency and quality-of-life measures over time. At study end, there were no significant differences in OAB outcomes between men and women.

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