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IP23-22 RADIOTHERAPY HISTORY IS NOT ASSOCIATED WITH FUNCTIONAL SATISFACTION AND QUALITY OF LIFE OUTCOMES IN PATIENTS WITH ARTIFICIAL URINARY SPHINCTERS
Abstract   Peer reviewed

IP23-22 RADIOTHERAPY HISTORY IS NOT ASSOCIATED WITH FUNCTIONAL SATISFACTION AND QUALITY OF LIFE OUTCOMES IN PATIENTS WITH ARTIFICIAL URINARY SPHINCTERS

Vishu Chandrasekhar, Melissa Kaufman, Andrew Peterson, Alex Vaney, LeRoy Jones, Joshua Broghammer, Gerard Henry, Benjamin Breyer, Bradley Erickson, Arthur Burnett, …
The Journal of urology, Vol.215(5S), e475
05/2026
DOI: 10.1097/01.JU.0001191400.40198.e5.22

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Abstract

INTRODUCTION AND OBJECTIVES: The artificial urinary sphincter (AUS) is considered a gold standard for moderate-to-severe incontinence in men following prostatectomy. While AUS placement following adjuvant RT for prostate cancer is increasingly common, these individuals’ experience remains poorly defined. This secondary analysis examined functional satisfaction and quality of life (QOL) outcomes of the AMS 800™ AUS in patients who have received radiation for prostate cancer compared to those who have not. METHODS: The Artificial Urinary Sphincter Clinical Outcomes Trial (AUSCO) was a single-arm, prospective, multi-center study which evaluated AUS efficacy and safety in men with primary stress urinary incontinence (SUI). Demographic information, medical history, pad weight, pads per day, voiding diaries, and the Incontinence Quality of Life (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L Questionnaire were recorded at baseline. Information on participant adverse events, revisions and device deficiencies were recorded with follow-up through 12 months, with additional data collection time points at activation, 3 and 6 months. Statistical analyses focused on comparing covariates and outcomes between subjects with history of pelvic radiotherapy versus those not exposed. RESULTS: Of 115 implanted subjects, 25 had undergone pelvic radiation. We observed no differences in baseline demographics or medical history between subgroups. No differences were seen between the radiated and nonradiated cohorts with respect to adverse events, device deficiencies, or revision. No differences were observed between subgroups on incontinence outcomes (pad weight, pads per day, SUI events on voiding diaries) or the QOL outcomes (I-QOL total and domain scores, IIQ-7 score, EQ-5D-5L) (Tables 1 and 2). CONCLUSIONS: Incontinence and QOL outcomes did not differ significantly between radiated and non-radiated patients up to 12 months following AUS. This study highlights the necessity to further explore how RT history should be considered when discussing options for men with incontinence after prostatectomy.

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