Abstract
Immune-related adverse events in melanoma: A nationwide analysis 2016
Journal of clinical oncology, Vol.37(15_suppl), pp.e18253-e18253
05/20/2019
DOI: 10.1200/JCO.2019.37.15_suppl.e18253
Abstract
e18253
Background: Melanoma is an aggressive skin cancer. Immunotherapy is currently used as a first-line treatment for unresectable metastatic disease. Combination immunotherapy has been shown to improve overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) compared to single-agent immunotherapy. However, immunotherapy related adverse events (irAE's) are being increasingly seen. This study analyses the incidence of irAE's and the variation in the length of stay, and mortality. Methods: This is a retrospective cohort analysis of the 2016 NIS database. We identified hospitalizations with either primary or secondary diagnosis of Melanoma. Logistic regression of irAE's such as pneumonitis, colitis, hypophysitis, adrenal insufficiency, encephalitis, myocarditis was performed. We evaluated the association between irAE's and various parameters. Results: We identified 13170 hospitalizations with primary or secondary diagnosis of melanoma. Univariate logistic regression showed pneumonitis (OR: 1.39; p value: < 0.01), hypophysitis (OR: 20.61; p value < 001), adrenal insufficiency (OR: 10.36, p value = < 0.01), colitis (OR 23.94, p value < 001), myocarditis (OR: 1; p value was n/a), encephalitis (OR 1.71; p value was 0.5). Univariate logistic regression for LOS showed colitis (OR 1.23; p value: 0.01), adrenal insufficiency (OR 0.20; p value: 0.748), hypophysitis (OR -2.50; p value: 0), myocarditis no admissions, encephalitis (OR -2.15; p value 0.01). Univariate logistic regression for mortality showed pneumonitis (OR 6.07; p value: < 0.01), colitis (OR 0.86 p value: 0.721), adrenal insufficiency (OR 1; p value: 0.996). Conclusions: The above results suggest that the incidence of colitis is the highest among irAE’s in melanoma patients likely due to immunotherapy. Hypophysitis is the next most common side effect, it’s followed by adrenal insufficiency which can be life-threatening. A high index of suspicion and anticipation of the above complications can lead to their timely detection and treatment.
Details
- Title: Subtitle
- Immune-related adverse events in melanoma: A nationwide analysis 2016
- Creators
- Manoj P. Rai - Sparrow HospitalPrabhjot Singh Bedi - UPMC East, Pittsburgh, PA;Rohanlal Vishwanth - Michigan State UniversityFawzi Abu Rous - Michigan State UniversityShiva Shrotriya - Sparrow HospitalPrajwal Dhakal - University of Nebraska Medical Center
- Resource Type
- Abstract
- Publication Details
- Journal of clinical oncology, Vol.37(15_suppl), pp.e18253-e18253
- DOI
- 10.1200/JCO.2019.37.15_suppl.e18253
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 05/20/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984361717402771
Metrics
14 Record Views