Abstract
Impact Of Sodium Derangements In Patients Hospitalized With Atrial Fibrillation Without Heart Failure: A Nationwide Cohort Study
Journal of cardiac failure, Vol.30(1), p.254
01/2024
DOI: 10.1016/j.cardfail.2023.10.325
Abstract
Background
Sodium imbalance is common in patients hospitalized with heart failure (HF) and was found to be an independent factor for poor prognosis. Limited data exists on the effect of sodium level in atrial fibrillation (AF) without HF.
Objective
The aim of the study is to evaluate the effect of sodium imbalances in patients admitted with AF without HF.
Methods
We queried the National inpatient sample database from January 2016 to December 2019 to identify hospitalizations with AF using ICD 10 CM codes. Patients with secondary diagnosis of HF were excluded. The study cohort was then divided into Normonatremia, Hyponatremia(<125 mEq/L) and Hypernatremia(>145 mEq/L) groups. Chi-square test and multivariate logistic regression were used to analyze the association. All statistical analyses were performed using weighted values.
Results
A total of 8,686,433 patients were identified with AF and without HF and 87.3% (n= 7,622,028) had normal sodium concentrations, 9.3% (n=807,820) hyponatremia and 3% (n= 256,585) had hypernatremia. Baseline characteristics and outcomes are shown in the table. The in-hospital mortality of normonatremia, hyponatremia and hypernatremia are 3.5%, 5.5% and 15.5% (p<0.001) respectively. After adjusting for age, sex, race, and comorbidity index all-cause in-hospital mortality was significantly higher in both hyponatremia [aOR=1.178, 95% CI 1.165-1.191(p<0.001)] and hypernatremia groups [aOR=1.17, 95% CI 1.69-1.71(p<0.001)].
Conclusion
In patients admitted with HF and had concurrent AF, hypernatremia was associated with higher in-hospital mortality, greater length of stay and higher hospital cost.
Details
- Title: Subtitle
- Impact Of Sodium Derangements In Patients Hospitalized With Atrial Fibrillation Without Heart Failure: A Nationwide Cohort Study
- Creators
- Akhilesh BabbiliAmith Reddy SeriSahith Reddy ThotamgariPaari Dominic
- Resource Type
- Abstract
- Publication Details
- Journal of cardiac failure, Vol.30(1), p.254
- DOI
- 10.1016/j.cardfail.2023.10.325
- ISSN
- 1071-9164
- eISSN
- 1532-8414
- Language
- English
- Date published
- 01/2024
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984543458902771
Metrics
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