Abstract
Increases in Cardiac Output Recruit Intrapulmonary Shunt Pathways in the Rat
The FASEB journal, Vol.24(S1), pp.1061.2-1061.2
04/2010
DOI: 10.1096/fasebj.24.1_supplement.1061.2
Abstract
Using an intact, spontaneously breathing, instrumented rat model, we investigated the effects of progressive embolization and pulmonary blood flow on intrapulmonary shunt pathway (IPAVs) recruitment. We hypothesized that progressive embolization and increased regional flow would recruit IPAVs in a dose‐dependent manner. We injected six boluses of 5×105 15μm spheres (3×106 total) in 0.4 or 0.8 mL aliquots via the inferior vena cava and harvested the kidney to assess transpulmonary passage of spheres. Spheres bypassed the lungs in 1/3 rats and 3/3 rats injected with 0.4 and 0.8 mL, respectively. The shunt fraction increased in a dose‐dependent manner with progressive embolization. Interestingly, right ventricular systolic pressure (RVSP) rose in the rats receiving 0.4mL injections (28±4 to 36±15 mmHg), but not in animals receiving 0.8 mL (24±3 mmHg vs 24±1mmHg). The transiently higher cardiac output associated with the larger volume injections may recruit and distend the pulmonary vasculature, including IPAVs, resulting in lower RVSP and greater sphere passage. These data suggest that increased pulmonary blood flow is important for IPAV recruitment. Further studies are needed to better define the mechanical and mediator‐based mechanisms regulating IPAVs and their importance in determining pulmonary vasculature pressure.
This research was supported by a grant from the NIH (5R01HL086897‐02).
Details
- Title: Subtitle
- Increases in Cardiac Output Recruit Intrapulmonary Shunt Pathways in the Rat
- Creators
- Melissa Bates - The University of WisconsinDavid Pegelow - The University of WisconsinBrendan Fulmer - The University of WisconsinAlyssa Drezdon - The University of WisconsinEmily Farrell - The University of WisconsinMarlowe Eldridge - The University of Wisconsin
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.24(S1), pp.1061.2-1061.2
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.1061.2
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (5R01HL086897‐02)
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984288738802771
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