Irregular shrinkage of tumor volume in cervical cancer during radiation therapy and its impact on the assessment method of response using magnetic resonance imaging

N.A Mayr; T Taoka; W.T Yuh; S.L Meeks; A.C Paulino; M Adli; V.A Magnotta; J.I Sorosky; J.M Buatti; R.C Gaston

doi:10.1016/S0360-3016(01)02437-3

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Irregular shrinkage of tumor volume in cervical cancer during radiation therapy and its impact on the assessment method of response using magnetic resonance imaging

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Irregular shrinkage of tumor volume in cervical cancer during radiation therapy and its impact on the assessment method of response using magnetic resonance imaging

N.A Mayr, T Taoka, W.T Yuh, S.L Meeks, A.C Paulino, M Adli, V.A Magnotta, J.I Sorosky, J.M Buatti and R.C Gaston

International journal of radiation oncology, biology, physics, Vol.51(3), pp.333-333

2001

DOI: 10.1016/S0360-3016(01)02437-3

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Abstract

Purpose: To determine temporal changes of tumor irregularity in cervical cancer during/after radiation therapy (RT) and their impact on the method of tumor volume measurement (simple diameter-based measurement vs. quantitative 3-D volumetry) for response assessment during/after RT. Materials and Methods: Serial MRI examinations were performed in 60 advanced cervical cancer patients at the start of RT, at 2-2.5 weeks of RT, at 4-5 weeks, and 1-2 months post-RT. Tumor configuration/morphology was classified as well-defined (round/oval) vs. lobulated vs. irregular/infiltrating. Tumor size was assessed by (a) ROI-based 3-D volumetry using quantitative image analysis and (b) measurement of the 3 orthogonal diameters (d1,d2, d3) on film hard copies with computation as an ellipsoid (volume = d1 x d2 x d3 x π/6). Serial tumor volume was compared between the two measurement methods. Results: Tumor configuration became increasingly irregular during RT. The proportion of lobulated and irregular/infiltrating tumors increased during RT and declined post-RT (68% pre-RT, 80% at 2-2.5 weeks, 72% at 4-5 weeks of RT, 33% post-RT). Accordingly, ROI-based 3-D volumetry and diameter-based tumor size correlated well pre-RT (r2 = 0.89) and post-RT (r2 = 0.80), but poorly during RT (r2 = 0.17 at 2-2.5 weeks of RT, r2 = 0.69 at 4-5 weeks of RT), when the assessment of regression rate is essential for prediction of outcome. Conclusion: Cervical cancers regress in a non-uniform fashion during RT and undergo increasingly irregular configuration. Therefore measurement with 3-D ROI-based volumetry techniques, which can optimally measure irregular volumes, provides better assessment of radiation response during treatment than simple diameter-based measurement.

Details

Title: Subtitle: Irregular shrinkage of tumor volume in cervical cancer during radiation therapy and its impact on the assessment method of response using magnetic resonance imaging
Creators: N.A Mayr - University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
T Taoka - University of Iowa College of Medicine, Iowa City, IA, USA
W.T Yuh - University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
S.L Meeks - University of Iowa College of Medicine, Iowa City, IA, USA
A.C Paulino - University of Iowa College of Medicine, Iowa City, IA, USA
M Adli - University of Iowa College of Medicine, Iowa City, IA, USA
V.A Magnotta - University of Iowa College of Medicine, Iowa City, IA, USA
J.I Sorosky - University of Iowa College of Medicine, Iowa City, IA, USA
J.M Buatti - University of Iowa College of Medicine, Iowa City, IA, USA
R.C Gaston - University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Resource Type: Abstract
Publication Details: International journal of radiation oncology, biology, physics, Vol.51(3), pp.333-333
DOI: 10.1016/S0360-3016(01)02437-3
ISSN: 0360-3016
eISSN: 1879-355X
Publisher: Elsevier Inc
Language: English
Date published: 2001
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984066389702771

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