Abstract
Keratoacanthoma biology and regression in mouse models (397.1)
The FASEB journal, Vol.28(S1), p.n/a
04/2014
DOI: 10.1096/fasebj.28.1_supplement.397.1
Abstract
We have described a novel mouse model of non‐melanoma skin cancer driven by skin‐specific expression of Zmiz1. These mice spontaneously developed keratoacanthomas and we have morphologically distinguished the biology of these tumors. Keratoacanthomas followed a growth pattern similar to that described in humans from a growth phase through a mature phase and into a regression phase. Even though the growth phase commonly had foci of atypia, high mitotic rate and minor local invasion, the tumors did not progress to malignancy. Similarly, we observed that RAG‐2‐deficient mice also developed keratoacanthomas and these followed a similar morphologic progression as did the Zmiz1 model. Using immunohistochemistry we characterized leukocyte infiltration during regression. In both models there was infiltration of macrophages and granzyme B‐immunoreactive cells. While an influx of T cells into the tumor epithelium was noted in Zimz1 mice, this was not found in RAG‐2‐deficient mice, suggesting that functional adaptive immunity is not required for regression. In these models, keratoacanthoma biology followed a consistent pattern of growth through mature and regressive phases. As commonly suggested in humans, these keratoacanthomas followed a benign course. The regression of these murine keratoacanthomas without adaptive immunity suggests that the innate immune system could be a target for treatment.
Grant Funding Source: R01CA132962‐01A2 (NCI) and Aiming For a Cure Foundation
Details
- Title: Subtitle
- Keratoacanthoma biology and regression in mouse models (397.1)
- Creators
- Katherine Gibson‐CorleyLaura Rogers - University of IowaAdam DupuyDavid Meyerholz
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.28(S1), p.n/a
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.28.1_supplement.397.1
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- Aiming For a Cure Foundation NCI (R01CA132962‐01A2)
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Pathology; Holden Comprehensive Cancer Center; Anatomy and Cell Biology; The University of Iowa Institute for Vision Research
- Record Identifier
- 9984288755602771
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