Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells

Xiangbing Meng; Pavla Brachova; Shujie Yang; Zhi Xiong; Yuping Zhang; Kimberly K Leslie

doi:10.17077/2154-4751.1100

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Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells

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Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells

Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang and Kimberly K Leslie

Proceedings in obstetrics and gynecology, Vol.2(1), pp.1-2

06/27/2011

DOI: 10.17077/2154-4751.1100

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Abstract

Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.

Details

Title: Subtitle: Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells
Creators: Xiangbing Meng - University of Iowa
Pavla Brachova - University of Iowa
Shujie Yang - University of Iowa
Zhi Xiong - University of Iowa
Yuping Zhang - University of Iowa
Kimberly K Leslie - University of Iowa
Resource Type: Abstract
Publication Details: Proceedings in obstetrics and gynecology, Vol.2(1), pp.1-2
DOI: 10.17077/2154-4751.1100
ISSN: 2154-4751
eISSN: 2154-4751
Language: English
Date published: 06/27/2011
Academic Unit: Obstetrics and Gynecology; Pathology
Record Identifier: 9984201252402771

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