Abstract
MBCL-24. INCIDENCE AND RISK FACTORS OF POSTERIOR FOSSA SYNDROME IN CHILDREN WITH POSTERIOR FOSSA TUMORS
Neuro-oncology (Charlottesville, Va.), Vol.20(suppl_2), pp.i121-i122
International Symposium on Pediatric Neuro-Oncology
06/22/2018
DOI: 10.1093/neuonc/noy059.420
PMCID: PMC6012482
Abstract
Abstract
BACKGROUND
The pathophysiology of posterior fossa syndrome (PFS) are not completely unraveled and its unpredictable outcome makes the clinical management of PFS challenging.
OBJECTIVE
To examine the incidence, clinical outcome and prognostic risk factors for PFS.
METHODS
The retrospective chart review from 1976 to March 2017 was conducted and medical records of 87 children with posterior fossa tumors were analyzed to look for outcomes, clinical variables such as tumor type, presentation and surgical methods. Pre- and post-operative MRI features of 64 patients were evaluated whether a damage was present or not in an anatomical structure for PFS prediction using a chi-square test.
RESULTS
Of the 87 charts reviewed 48 (55%) had medulloblastoma, 26 (30%) had low grade glioma, 10 (11%) had ependymoma, and 3 (3%) had ATRT. Fifteen (17%) patients developed PFS, 10 (67%) had medulloblastoma, 2 (13%) had low grade glioma, 2 (13%) had ATRT, and 1 (7%) had ependymoma. Ten out of 15 patients (67%) with PFS had severe PFS symptoms. Among observed clinical variables, the intraoperative incision in the vermis was highly associated with the incidence of PFS (p=0.009). In the post-operative MRI, the damage of bilateral dentate nuclei and superior cerebellar peduncles were detected significantly in PFS (P=0.008 and p=0.018, respectively).
CONCLUSION
Symptoms of PFS vary thus retrospective chart review may underestimate the actual incidence. Post-operative MRI findings may be predictive of PFS and may lead to prevention or to early interventions.
Details
- Title: Subtitle
- MBCL-24. INCIDENCE AND RISK FACTORS OF POSTERIOR FOSSA SYNDROME IN CHILDREN WITH POSTERIOR FOSSA TUMORS
- Creators
- Mariko Sato - University of Iowa, Iowa City, IA, USADemi Eble - University of Iowa, Iowa City, IA, USATomoaki Sasaki - University of Iowa, Iowa City, IA, USABridget Zimmerman - University of Iowa, Iowa City, IA, USAArnold Menezes - University of Iowa, Iowa City, IA, USAJeremy Greenlee - University of Iowa, Iowa City, IA, USASaul Wilson - University of Iowa, Iowa City, IA, USABrian Dlouhy - University of Iowa, Iowa City, IA, USASatsuki Matsumoto - University of Iowa, Iowa City, IA, USAAaron Boes - University of Iowa, Iowa City, IA, USASue O’Dorisio - University of Iowa, Iowa City, IA, USA
- Resource Type
- Abstract
- Publication Details
- Neuro-oncology (Charlottesville, Va.), Vol.20(suppl_2), pp.i121-i122
- Conference
- International Symposium on Pediatric Neuro-Oncology
- Publisher
- Oxford University Press; US
- DOI
- 10.1093/neuonc/noy059.420
- PMCID
- PMC6012482
- ISSN
- 1522-8517
- eISSN
- 1523-5866
- Alternative title
- Abstracts from the 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) June 30 – July 3, 2018 Hyatt Regency Hotel Denver, Colorado, USA
- Language
- English
- Date published
- 06/22/2018
- Academic Unit
- Neurosurgery; Psychiatry; Roy J. Carver Department of Biomedical Engineering; Neurology; Otolaryngology; Iowa Neuroscience Institute; Stead Family Department of Pediatrics; Biostatistics; Neurology (Pediatrics)
- Record Identifier
- 9984071952302771
Metrics
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