Abstract
Multimorbidity patterns in people with Alzheimer’s disease
Alzheimer's & dementia, Vol.19(S5), e064414
06/2023
DOI: 10.1002/alz.064414
Abstract
Background
Multimorbidity is highly impactful for older adults, especially when it co‐occurs with Alzheimer’s disease (AD). However, scarce evidence is available about comorbid conditions co‐occurring with AD. We aimed to identify the most prevalent comorbid conditions and examine the common multimorbidity patterns in patients with AD.
Method
Using electronic health records of a university hospital, we extracted data from 2,646 older adults with AD (ICD‐10) using Calderón‐Larrañaga’s inventory of chronic conditions. Leverage correlation was performed to detect multimorbidity patterns.
Result
AD patients had on average 13 comorbid conditions and 50% of them had at least 10 comorbid conditions co‐occurring with AD. Hypertension (51.7%), lipoprotein metabolism disorders and other lipidemia (35%), depression (33.9%), general mental disorders (31.96%), sleep disorders (26%), urinary disorders (25.3%), anemia (24.6%), joint disorders (23.19%), chronic kidney disease (21.25%), and other functional intestinal disorders (20.66%) were the top 10 prevalent comorbid conditions. The common multimorbidity patterns were “disorders of lipoprotein metabolism and other lipidemia” and “hypertension” (frequency [n = 747, 30%]; leverage:0.09), followed by “hypertension” and “hypertensive kidney disease” (frequency [n = 189, 8%]; leverage:0.06), “presence of cardiac and vascular implants and grafts” and “disorders of lipoprotein metabolism and other lipidemias” (frequency [n = 181,7%; leverage:0.05), and “Type 2 diabetes” and “hypertension (frequency [n = 181,7%; leverage:0.05).”
Conclusion
Our results align with prior studies that cardiovascular disease, diabetes, osteoarthritis, and depression are common conditions in people with AD. These findings might support future studies investigating the mechanisms linking multimorbidity to AD, which ultimately can guide preventive actions and comprehensive approaches for managing these co‐occurring conditions.
Details
- Title: Subtitle
- Multimorbidity patterns in people with Alzheimer’s disease
- Creators
- Nai‐Ching Chi - University of IowaPatrick Lozier - University of IowaNick Street - University of IowaKathleen Buckwalter - University of IowaSue Gardner - University of IowaBarbara Rakel - University of IowaYelena Perkhounkova - University of IowaMaria Hein - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Alzheimer's & dementia, Vol.19(S5), e064414
- DOI
- 10.1002/alz.064414
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Number of pages
- 1
- Language
- English
- Date published
- 06/2023
- Academic Unit
- Bus Admin College; Health Management and Policy; Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Computer Science; Business Analytics; Research Dept
- Record Identifier
- 9984430333902771
Metrics
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