Abstract
Muscle sympathetic nerve activity is positively related to aortic wave reflection characteristics in postmenopausal women
The FASEB journal, Vol.25, pp.842.1-842.1
04/2011
DOI: 10.1096/fasebj.25.1_supplement.842.1
Abstract
Aortic wave reflection characteristics such as augmentation index are positively related to muscle sympathetic nerve activity (MSNA) in young men. In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal (PM) women. MSNA (peroneal microneurography) and arterial pressure (brachial line) were measured in 8 PM (age; mean ± SEM, 58 ± 2 yrs) and 20 young women (25 ± 1 yrs). Aortic wave form characteristics were synthesised from radial arterial pressure waves (applanation tonometry). Specifically, augmentation index (AI, %), wave reflection amplitude (AG, mmHg) and estimated wasted left ventricular energy (EW, dines/cm2/s) were calculated. Tonic MSNA was higher in PM vs. young women (64 ± 5 vs. 24 ± 4 bursts/100 heart beats). All indices of aortic wave reflection were higher in the PM vs. young women (P<0.05). Baseline MSNA was inversely related to AI (r = −0.63, P<0.05), AG (r = −0.62, P<0.05) and Ew (r = −0.61, P<0.05) in young women. Interestingly, baseline MSNA was positively related to AI (r = 0.64; P=0.09), AG (r = 0.71, P<0.05) and Ew (r = 0.80, P<0.05) in PM women. Thus high levels of MSNA are associated with higher indexes of arterial stiffness in PM women. This may provide insights into why there is an increase in cardiovascular events in PM women. NIH HL‐083947 (MJJ, NC); AR‐55819 (DPC), AHA 2170087 (ECH), and CTSA RR‐024150.
Details
- Title: Subtitle
- Muscle sympathetic nerve activity is positively related to aortic wave reflection characteristics in postmenopausal women
- Creators
- Emma HartNisha Charkoudian - Mayo Clinic in FloridaMichael J JoynerTimothy B CurryDarren P Casey
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.25, pp.842.1-842.1
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.842.1
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294931402771
Metrics
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